856859-99-9Relevant academic research and scientific papers
First organophosphorus radical-mediated cyclisations to afford medium-sized rings: Eight-membered lactones and seven- and eight-membered lactams
Lang, Stuart,Corr, Michael,Muir, Neil,Khan, Tanweer A.,Sch?nebeck, Franziska,Murphy, John A.,Payne, Andrew H.,Williams, Andrew C.
, p. 4027 - 4030 (2005)
The phosphorus based radical precursors N-ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO) are efficient reagents for carrying out the formation of seven- and eight-membered rings. Esters and amides were successfully converted into the corresponding eight-membered lactones and seven- and eight-membered lactams in good to excellent yields.
