856896-75-8Relevant academic research and scientific papers
From natural products to achiral drug prototypes: Potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs
Hanessian, Stephen,Therrien, Eric,Zhang, Jianbin,Otterlo, Willem van,Xue, Yafeng,Gustafsson, David,Nilsson, Ingemar,Fjellstroem, Ola
scheme or table, p. 5429 - 5432 (2010/05/19)
A series of dihydropyrid-2-ones was synthesized and tested for inhibitory activity against serine protease enzymes. Moderate to low nanomolar inhibitory activities were obtained against thrombin and excellent selectivity against trypsin was observed.
