857028-40-1Relevant academic research and scientific papers
The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating
Baxendale, Ian R.,Ley, Steven V.,Martinelli, Marisa
, p. 5323 - 5349 (2005)
Herein, we report on the preparation of a library of 5-substituted-2-amino- 1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-aminosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products.
