857048-92-1

Basic information

• Product Name: 2-(4-bromophenyl)-5-[(prop-2-yn-1-yloxy)methyl]furan
• Synonyms: 2-(4-bromophenyl)-5-[(prop-2-yn-1-yloxy)methyl]furan
• CAS NO: 857048-92-1
• Molecular Weight: 291.144
• Mol File: 857048-92-1.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)-5-[(prop-2-yn-1-yloxy)methyl]furan(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-5-[(prop-2-yn-1-yloxy)methyl]furan(857048-92-1)
• EPA Substance Registry System: 2-(4-bromophenyl)-5-[(prop-2-yn-1-yloxy)methyl]furan(857048-92-1)

Safety Data

• Hazardous Substances Data: 857048-92-1(Hazardous Substances Data)

Upstream product

• 20005-42-9 5-(4-bromophenyl)-2-furancarboxyaldehyde 
• 33342-28-8 [5-(4-bromophenyl)furan-2-yl]methanol 
• 106-96-7 propargyl bromide 

Downstream Products

• 1034250-41-3 2-(4-bromophenyl)-5-{[(3-D)prop-2-yn-1-yloxy]methyl}furan 
• 20005-42-9 5-(4-bromophenyl)-2-furancarboxyaldehyde 

Relevant articles and documents

Gold catalysis: Dihydroisobenzofurans and isochromanes by the intramolecular furan/alkyne reaction

A series of furyl alcohols and homofuryl alcohols was synthesized by reduction of furfurals or reaction of furyllithium compounds with epoxides and subsequent propargylation. The gold-catalyzed cycloisomerization of these products furnished dihydroisobenzofurans and isochromanes. Crystal structure analyses proved the sequence of the substituents for both classes of products. Unsaturated dicarbonyl compounds as side-products show the mechanistic relationship to the analogous platinum-catalyzed reactions. Neither ester groups, even on the 4-position of the furan ring, nor aryl bromides hinder the catalysis by gold. In the case of a substrate with an allyl ether in the side chain, a side-product, which provides evidence for a reaction of the alkyne with an inverse regioselectivity, was observed.