857193-29-4Relevant academic research and scientific papers
Direct cyclic carbonate synthesis from CO2 and diol over carboxylation/hydration cascade catalyst of CeO2 with 2-cyanopyridine
Honda, Masayoshi,Tamura, Masazumi,Nakao, Kenji,Suzuki, Kimihito,Nakagawa, Yoshinao,Tomishige, Keiichi
, p. 1893 - 1896 (2014)
We first achieved direct synthesis of propylene carbonate from CO 2 and 1,2-propanediol in excellent yield (>99%) using a carboxylation/hydration cascade catalyst of CeO2 with 2-cyanopyridine. The catalyst system can be applied to syntheses of various cyclic carbonates, including 6-membered ring carbonates that are difficult to synthesize in high yields (62->99%).
Catalytic One-Pot Oxetane to Carbamate Conversions: Formal Synthesis of Drug Relevant Molecules
Guo, Wusheng,Laserna, Victor,Rintjema, Jeroen,Kleij, Arjan W.
supporting information, p. 1602 - 1607 (2016/10/13)
Oxetanes are versatile building blocks in drug-related synthesis to induce property-modulating effects. Whereas related oxiranes are widely used in coupling chemistry with carbon dioxide (CO2) to afford value-added commodity chemicals, oxetane/CO2couplings remain extremely limited despite the recent advances in the synthesis of these four-membered heterocycles. Here we report an effective one-pot three-component reaction (3CR) strategy for the coupling of (substituted) oxetanes, amines and CO2to afford a variety of functionalized carbamates with excellent chemoselectivity and good yields. The process is mediated by an aluminium-based catalyst under relatively mild conditions and the developed catalytic methodology can be applied to the formal synthesis of two pharmaceutically relevant carbamates with the 3CR being a key step. (Figure presented.).
Synthesis of cyclic carbonates from diols and CO2 catalyzed by carbenes
Bobbink, Felix D.,Gruszka, Weronika,Hulla, Martin,Das, Shoubhik,Dyson, Paul J.
supporting information, p. 10787 - 10790 (2016/09/07)
The synthesis of cyclic carbonates from epoxides and CO2 is a well-established reaction, whereas the synthesis of cyclic carbonates from diols and CO2 is considerably more challenging, and few efficient catalysts are available. Here, we describe heterocyclic carbene catalysts, including one derived from a cheap and efficient thiazolium salt, for this latter reaction. The reaction proceeds at atmospheric pressure in the presence of an alkyl halide and Cs2CO3. Reaction mechanisms for the transformations involved are also proposed.
SYNTHESIS OF CYCLIC CARBONATES
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Page/Page column 23; 25; 31; 32; 33, (2014/11/11)
The present invention provides a method of synthesizing a cyclic carbonate comprising the step of reacting an alcohol with carbon dioxide.in the presence of a base.
Synthesis of cyclic carbonates with carbon dioxide and cesium carbonate
Reithofer, Michael R.,Sum, Yin Ngai,Zhang, Yugen
, p. 2086 - 2090 (2013/09/24)
Cyclic carbonates are important compounds for the synthesis of biocompatible polymers and linear dialkyl carbonates, as well as solvents and electrolytes. We report here the synthesis of such compounds from easily accessible starting materials with carbon dioxide as a C1 source and caesium carbonate as the base. This new methodology is able to yield 5- and 6-membered cyclic carbonates very efficiently in a green manner.
