857232-60-1

Basic information

• Product Name: 1,3-Propanedione, 1-(2-hydroxy-5-methoxyphenyl)-3-(4-nitrophenyl)-
• CAS NO: 857232-60-1
• Molecular Formula: C16H13NO6
• Molecular Weight: 315.282
• Mol File: 857232-60-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Propanedione, 1-(2-hydroxy-5-methoxyphenyl)-3-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanedione, 1-(2-hydroxy-5-methoxyphenyl)-3-(4-nitrophenyl)-(857232-60-1)
• EPA Substance Registry System: 1,3-Propanedione, 1-(2-hydroxy-5-methoxyphenyl)-3-(4-nitrophenyl)-(857232-60-1)

Safety Data

• Hazardous Substances Data: 857232-60-1(Hazardous Substances Data)

Upstream product

• 332103-23-8 4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester 
• 1007476-32-5 sodium ethyl acetylacetate enolate 

Downstream Products

• 250262-43-2 6-methyl-2-(4-nitrophenyl)-4H-chromen-4-one 
• 39679-61-3 6-methoxy-2-(4-nitrophenyl)-4H-chromen-4-one 

Relevant articles and documents

99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques

Two 99mTc/Re complexes based on flavone and aurone were tested as potential probes for imaging β-amyloid plaques using single photon emission computed tomography. Both 99mTc-labeled derivatives showed higher affinity for Aβ(1-42) aggregates than did 99mTc-BAT. In sections of brain tissue from an animal model of AD, the Re-flavone derivative 9 and Re-aurone derivative 19 intensely stained β-amyloid plaques. In biodistribution experiments using normal mice, 99mTc-labeled flavone and aurone displayed similar radioactivity pharmacokinetics. With additional modifications to improve their brain uptake, 99mTc complexes based on the flavone or aurone scaffold may serve as probes for imaging cerebral β-amyloid plaques.

COMPOSITION FOR AMYLOID-ASSOCIATED DISEASE DIAGNOSIS

A composition for diagnosing amyloid-related diseases, which comprises a flavone derivative, a chalcone derivative, a styrylchromone derivative, or a coumarin derivative, is provided. These compounds have high binding specificity to an amyloid β protein,