250262-43-2

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 1351986-48-5 2-(4-nitrobenzoyloxy)-5-methyl-benzoylmethyltriphenylphosphonium bromide 
• 106-44-5 p-cresol 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 62-23-7 4-nitro-benzoic acid 
• 36695-22-4 1-[2-(4-nitrobenzoyloxy)-5-methylphenyl]-2-bromoethanone 
• 36695-11-1 1-[2-(4-nitrobenzoyloxy)-5-methylphenyl]-ethanone 
• 857232-60-1 1-(5-methoxy-2-hydroxyphenyl)-3-(4-nitrophenyl)propane-1,3-dione 
• 106149-34-2 1-(4-nitrophenyl)-3-[2-(1-hydroxy-4-methylphenyl)]propane-1,3-dione 

Downstream Products

• 1343513-03-0 C₁₈H₁₆N₂O₄ 
• 1343513-04-1 6-((1H-imidazol-1-yl)methyl)-2-(4-nitrophenyl)-4H-chromen-4-one 
• 1343513-05-2 N,N-diethyl-N-((2-(4-nitrophenyl)-4-oxo-4H-chromen-6-yl)methyl)ethanaminium 
• 1343513-16-5 2-(4-aminophenyl)-6-((diethylamino)methyl)-4H-chromen-4-one 
• 1343512-99-1 6-((diethylamino)methyl)-2-(4-nitrophenyl)-4H-chromen-4-one 
• 1343513-00-7 2-(4-nitrophenyl)-6-(piperidin-1-ylmethyl)-4H-chromen-4-one 
• 1343513-51-8 C₁₆H₁₀BrNO₄ 
• 1343513-01-8 6-((4-methylpiperazin-1-yl)methyl)-2-(4-nitrophenyl)-4H-chromen-4-one 
• 1343513-02-9 6-(morpholin-4-ylmethyl)-2-(4-nitrophenyl)-4H-chromen-4-one 

Relevant academic research and scientific papers

Investigation on the substitution effects of the flavonoids as potent anticancer agents: A structure-activity relationships study

Three series of flavonoid analogues substituted with different aminomethyl substitutions at C-6, C-7, and C-8 were designed and synthesized for the structure-activity relationship studies as potent anticancer agents. The prepared analogues were evaluated for their in vitro inhibitory activity against the growth of the hepatic cancer cell lines HepG2 and SMMC-7721. Structure-activity relationships indicated that not only the compounds with amino methyl groups were more active than those without the groups in the same series but also the compounds substituted by aminomethyl groups at position C-8 were more active than those at positions C-6 and C-7.

A new synthesis of flavones and pyranoflavone by intramolecular photochemical Wittig reaction in water

A new synthetic approach toward the synthesis of flavones and pyranoflavone has been developed by light induced intramolecular photochemical Wittig reaction in water onto aryloxycarbonyl groups and suitably substituted phosphonium bromides sans any phase transfer catalyst or promoter.

Mechanically activated solid-state synthesis of flavones by high-speed ball milling

An efficient, mechanically activated solid-state synthesis of flavones from 1-(2-hydroxyphenyl)-3-aryl-1,3-propanediones using high-speed ball milling is described. This method has notable advantages in terms of good yield, short reaction time, and neat conditions.

A facile synthesis of flavones catalysed by gallium(III) triflate

Ga(OTf)3 was explored as a novel catalyst for the cyclisation of 1-(2-hydroxyphenyl)-3-aryl-1,3-propanediones in nitromethane to flavones with excellent yields.

Manganese(III) acetate mediated oxidation of flavanones: A facile synthesis of flavones

Oxidation of flavanones (1a-o) with manganese(III) acetate by heating in acetic acid in presence of perchloric acid afforded exclusively flavones (2a-o) by dehydrogenation in almost quantitative yields. Copyright Taylor & Francis, Inc.

FeCl3 catalyzed dehydrative cyclisation of 1, 3 - (diaryl diketones) to flavones

FeCl3 in catalytic amount effects smooth conversion of substituted 1- (2-hydroxy phenyl) - 3 - phenyl - 1, 3 - propanediones to the corresponding flavones in high yields.

An environmentally benign synthesis of flavones from 1,3-diketones using silica gel supported NaHSO4 catalyst

A simple and enviromentaly benign method for synthesis of flavones is described via dehydrative cyclisation of o-hydroxydibenzoylmethane using silica gel supported NaHSO4 catalyst.

Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex

The affinities for the benzodiazepine binding site of the GABA(A) receptor of 21 flavonoids have been studied using [3H]flumazenil binding to rat cortical membranes in vitro. We show that flavonoids with high affinity for the benzodiazepine receptor in vitro spanning the whole efficacy range from agonists (1q) to inverse agonists (1l) can be synthesized. The receptor binding properties of the flavonoids studied can successfully be rationalized in terms of a comprehensive pharmacophore model recently developed by cook and co-workers (Drug Des. Dev. 1995, 12, 193-248), supporting the validity of this model. However, in contrast to the requirement by the model that an interaction with the hydrogen bond-accepting site A2 is necessary for compounds to display inverse agonistic activity, 6-methyl-3'-nitroflavone (1l), which cannot engage in such an interaction, nevertheless displays inverse agonism. The analysis of the binding affinities of 3'- and 4'- substituted flavones in terms of the pharmacophore model has yielded new information for the further development of the pharmacophore model.