85728-62-7Relevant articles and documents
AIBN-initiated direct thiocyanation of benzylic sp3C-H with: N -thiocyanatosaccharin
Wu, Di,Duan, Yongjie,Liang, Kun,Yin, Hongquan,Chen, Fu-Xue
supporting information, p. 9938 - 9941 (2021/10/12)
Direct thiocyanations of benzylic compounds have been implemented. Here, a new strategy, involving a free radical reaction pathway initiated by AIBN, was used to construct the benzylic sp3 C-SCN bond. In this way, the disadvantage of other strategies involving introducing leaving groups in advance to synthesize benzyl thiocyanate compounds was overcome. The currently developed protocol also involved the use of readily available raw materials and resulted in high product yields (up to 100%), both being great advantages for synthesizing benzyl thiocyanates.
Method for preparing organic thiocyanide
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Paragraph 0034-0037, (2020/05/01)
The invention relates to a method for preparing organic thiocyanide. The method comprises the following steps: mixing a benzyl alcohol compound (I) as described in the specification, thiocyanate, an alkaline substance and an organic solvent, carrying out a reaction at 25-50 DEG C for 3-6 hours in an SO2F2 atmosphere, and carrying out after-treatment on a reaction solution to obtain organic thiocyanide (II) as described in the specification. According to the invention, cheap, easily available and environment-friendly SO2F2 is used as an accelerant to efficiently promote preparation of organic thiocyanide from alcohol and thiocyanate, so the step that halogen is introduced into a preset position of a molecular structure in advance in a traditional production process is omitted; and the method is applicable to a wide range of substrates, can prepare corresponding organic thiocyanide at a high yield, is simple in operation process, and is suitable for large-scale preparation.
One-pot synthesis of (ethoxycarbonyl)difluoromethylthioethers from thiocyanate sodium and ethyl 2-(trimethylsilyl)-2,2-difluoroacetate (TMS-CF2CO2Et)
Xu, Lijun,Wang, Hongyu,Zheng, Changwu,Zhao, Gang
, p. 6057 - 6066 (2017/09/23)
An efficient one-pot cascade methodology for the synthesis of (ethoxycarbonyl)difluoromethyl thioethers is described. Benzyl, allyl, alkyl halides or diazonium salts as the starting materials together with thiocyanate sodium and TMS-CF2CO2Et in the presence of CsF or NaOAc afford a variety of the fluoroalkylthiolated products in moderate to good yields.
