857335-01-4Relevant academic research and scientific papers
Functional group scope in the methylene-free, tandem enyne metathesis
Peppers, Brian P.,Kulkarni, Amol A.,Diver, Steven T.
, p. 2539 - 2542 (2006)
The methylene-free ring synthesis of 1,3-cyclohexadienes has been expanded to include a diverse set of functional group-rich terminal and internal alkynes.
Studies directed toward the synthesis of the scabrosins: validation of a tandem enyne metathesis approach
Middleton, Mark D.,Peppers, Brian P.,Diver, Steven T.
, p. 10528 - 10540 (2007/10/03)
A synthetic approach to the scabrosin family of antibiotics using a ruthenium carbene-catalyzed tandem metathesis and?a Pd(II)-catalyzed cyclization is described. The chiral propargyl amino acid is furnished through enantioselective phase-transfer proparg
Synthesis of 1,3-cyclohexadienes by tandem diene-alkyne metathesis: Improved procedure
Middleton, Mark D.,Diver, Steven T.
, p. 4039 - 4043 (2007/10/03)
A practical synthesis of 2-substituted 1,3-cyclohexadienes by the cross enyne metathesis between alkynes and 1,5-hexadiene is reported. The isolation of the 1,3-cyclohexadienes has been hampered by the formation of an inseparable triene by-product. The use of a second consecutive cross alkene metathesis to give water-soluble products allowed removal of this by-product. Using this one-pot procedure, a synthesis of cyclohexadienes from simple starting materials was developed. The procedure was used in a three-step synthesis of a functionalized tetrahydroquinoline using Pd(II)-catalyzed chloroacetoxylation (B?ckvall reaction) for cyclohexadiene functionalization.
