85743-01-7Relevant academic research and scientific papers
New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
Kim, Seung Ill,Lee, Seung Ho,Lee, Eung-Seok,Lee, Chong-Soon,Jahng, Yurngdong
, p. 785 - 789 (2012/08/29)
A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.
