857481-88-0Relevant academic research and scientific papers
NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME
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Page/Page column 17, (2010/12/29)
Novel polyspirane compounds used in the treatment of diseases involving parasites that belong to the phylum of apicomplexae, and a method for preparing the same.
Enhanced antimalarial activity of novel synthetic aculeatin derivatives
Peuchmaur, Marine,Sa?dani, Nadia,Botté, Cyrille,Maréchal, Eric,Vial, Henri,Wong, Yung-Sing
supporting information; experimental part, p. 4870 - 4873 (2009/07/25)
We report the design, synthesis, and in vitro evaluation of novel polyspirocyclic structures, inspired by the antimalarial natural products, the aculeatins. A divergent synthetic strategy was conceived for the practical supply and has allowed the discover
Synthesis of (±)-aculeatins A and B
Wong, Yung-Sing
, p. 686 - 687 (2007/10/03)
The first synthesis of two new antiprotozoal and natural products was performed using concomitant deprotecting dithiane-phenolic oxidative reactions to form in one-step the 1,7-dioxadispiro [5.1.5.2]pentadecane core.
