58608-98-3Relevant articles and documents
Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones
Au, Chi-Ming,Ling, Cho-Hon,Sun, Wenlong,Yu, Wing-Yiu
supporting information, p. 3310 - 3314 (2021/05/29)
We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.
Synthesis of the pyoverdin chromophore by a biomimetic oxidative cyclization
Jones, Raymond C.F.,Yau, Sze Chak,Iley, James N.,Smith, Janet E.,Dickson, James,Elsegood, Mark R.J.,McKee, Vickie,Coles, Simon J.
scheme or table, p. 1519 - 1522 (2009/09/06)
The fluorescent dihydropyrimido[1,2-a]quinoline chromophore of the pyoverdin siderophores has been synthesized by a biomimetic oxidative cyclization using an iodine (III) reagent, followed by elimination and dehydrogenation.
Enhanced antimalarial activity of novel synthetic aculeatin derivatives
Peuchmaur, Marine,Sa?dani, Nadia,Botté, Cyrille,Maréchal, Eric,Vial, Henri,Wong, Yung-Sing
supporting information; experimental part, p. 4870 - 4873 (2009/07/25)
We report the design, synthesis, and in vitro evaluation of novel polyspirocyclic structures, inspired by the antimalarial natural products, the aculeatins. A divergent synthetic strategy was conceived for the practical supply and has allowed the discover