56762-32-4

Usage

Uses

Used in Pharmaceutical Synthesis:
Ethanone,1-(2-amino-3-chlorophenyl)is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its chemical properties allow for the creation of new molecules with potential therapeutic effects, contributing to the development of novel drugs and treatments.
Used in Organic Compound Synthesis:
In the chemical industry, Ethanone,1-(2-amino-3-chlorophenyl)serves as a versatile building block for the synthesis of a wide range of organic compounds. Its unique structure facilitates the formation of diverse molecules with various applications, including but not limited to, dyes, pigments, and other specialty chemicals.
Used in Research and Development:
Ethanone,1-(2-amino-3-chlorophenyl)is also employed in research and development settings, where its chemical properties are explored for potential applications in new technologies and innovations. Its reactivity and structural features make it a valuable tool for scientists working on the cutting edge of chemical and material sciences.
Used in Safety and Hazard Mitigation:
Given its potential toxicity and other hazards, Ethanone,1-(2-amino-3-chlorophenyl)is also used in the development of safety protocols and hazard mitigation strategies. Understanding its properties and potential risks allows for the implementation of proper handling and storage procedures, ensuring the safety of workers and the environment.

InChI:InChI=1/C8H8ClNO/c1-5(11)6-3-2-4-7(9)8(6)10/h2-4H,10H2,1H3

Upstream product

• 4771-47-5 3-chloro-2-nitro-benzoic acid 
• 19088-99-4 3-chloro-2-nitrobenzoyl chloride 
• 7137-38-4 1-(3-chloro-2-nitrophenyl)ethan-1-one 
• 53312-77-9 2-amino-3-chlorobenzonitrile 
• 676-58-4 methylmagnesium chloride 
• 75-16-1 methylmagnesium bromide 
• 95-51-2 o-chloroaniline 
• 533-17-5 N-(2-chlorophenyl)acetamide 

Downstream Products

• 1429782-16-0 N-(2-acetyl-6-chlorophenyl)-2,2,2-trichloroacetamide 
• 857594-97-9 2-chloro-6-(prop-1-en-2-yl)aniline 

Relevant academic research and scientific papers

Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks

Described herein is an unusual Cp*CyRh(III)-catalyzed intramolecular site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams with broad substrate/functional group tolerance. Experimental and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.

SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES

The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymallytransformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.

Water-Soluble Hypervalent Iodine(III) Having an I-N Bond. A Reagent for the Synthesis of Indoles

A readily accessible and bench-stable water-soluble hypervalent iodine(III) reagent (phenyliodonio)sulfamate (PISA) with an I-N bond was synthesized, and its structure was characterized by X-ray crystallography. With PISA, various indoles were synthesized via C-H amination of 2-alkenylanilines involving an aryl migration/intramolecular cyclization cascade with excellent regioselectivity in aqueous CH3CN. Notably, using this new method as the key step, not only two drug molecules, indometacin and zidometacin, but also another bioactive molecule, pravadoline, were synthesized.

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

Photo-Fries rearrangement of aryl acetamides: Regioselectivity induced by the aqueous micellar green environment

Photochemical reactions tend to give more than one photoproduct. However, such a reaction can be a powerful synthetic tool when it is possible to conduct it in regioselective conditions yielding a single photoproduct. Water-surfactant solutions as reaction media can be considered as an approach in this context because they show products with different features than those from isotropic solutions. Here we describe results obtained from studying the effect on the prototypical photoreaction, known as the photo-Fries reaction of several substituted acetanilides and α-naphthyl acetamide within surfactant micelles (ionic and non-ionic micelles). This reaction involves homolytic cleavage of a C-N bond to yield a singlet radical pair. The surfactant micelles control the rotational and translational mobility of the radical pair, resulting in noticeable photoproduct selectivity.

QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS

This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The pr