857636-32-9Relevant academic research and scientific papers
Enantioselective cycloadditions with α,β-disubstituted acrylimides
Sibi, Mukund P.,Ma, Zhihua,Itoh, Kennosuke,Prabagaran, Narayanasamy,Jasperse, Craig P.
, p. 2349 - 2352 (2005)
(Chemical Equation Presented) The use of N-H imide templates provides a solution to the problem of rotamer control in Lewis acid catalyzed reactions of α,β-disubstituted acryloyl imides. Reactions proceed through the s-cis rotamer and with improved reactivity because A1,3 strain is avoided. Enantioselective nitrone, nitrile oxide, and Diels-Alder cycloadditions demonstrate the principle.
