85768-32-7

Upstream product

• 937-64-4 4-chlorophenyl chlorothionoformate 
• 85768-12-3 4-nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-ethylthio-azetidin-2-on-1-yl]-acetate 
• 85768-31-6 4-Nitrobenzyl 2-[3(S)-{1(R)-dimethyl-(2-methylprop-2-yl)silyloxyethyl}-4(R)-ethylthioazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio propenoate 

Downstream Products

• 85768-33-8 4-Nitrobenzyl 2-[3(S)-{1(R)-hydroxyethyl}-4(S)-chloroazetidin-2-on-1-yl]-3-(4-chlorophenoxy)-3-trimethylacetylthio-propenoate 
• 85768-34-9 (5R,6S)-6-<(R)-1-Hydroxyethyl>-2-(4-chlorophenyl)oxypenem 

Relevant academic research and scientific papers

Antibacterial penem derivatives

Antibacterially active penem compounds and salts of the formula STR1 wherein R is hydrogen or an esterifying group, R2 is hydrogen, hydroxy, or protected hydroxy, and R1 is phenyl, naphthyl, thienyl, pyridyl, quinolyl, or isoquinolyl, or such a group which is mono-, di-, or tri-substituted; methods for making such compounds or salts; and antibacterial pharmaceutical preparations containing the compounds or salts.

Stereoselective Synthesis of a (5R,6S)-6--2-aryloxypenem

(5R,6S)--2-aryloxypenems can be synthesised through hydroxy group directed chlorinolysis of the (3S,4R)-3--4-ethylthioazetidinone (8) to the (4S)-4-chloroazetidinone (9) with subsequent cyclisation.