85778-06-9Relevant academic research and scientific papers
(R)- and (S)-Proline-Derived Chiral Phosphoramides as Organo catalysts for the Enantiodivergent Aldol Reaction of Isatins with Cyclohexanone in the Presence of Water
Cruz-Hernández, Carlos,Hernández-González, Perla E.,Juaristi, Eusebio
, p. 1827 - 1840 (2018)
Novel organocatalysts derived from (R)- and (S)-proline and incorporating a chiral phosphoramide fragment were rationally designed and subsequently synthesized. These chiral compounds catalyze the enantioselective aldol addition reaction of cyclohexanone
Development of C2-Symmetric Chiral Bifunctional Triamines: Synthesis and Application in Asymmetric Organocatalysis
Ca?ellas, Santiago,Alonso, Pedro,Pericàs, Miquel à.
supporting information, p. 4806 - 4810 (2018/08/24)
The synthesis and application of a newly designed C2-symmetric chiral bifunctional triamine family (C2-CBT) is reported. These enantiopure chiral triamine scaffolds can be accessed in multigram amounts from simple amino acids while avoiding chromatographic purification. As a proof of principle, C2-CBT has been studied in the aldol reaction of cyclic ketones with isatins, with the target tertiary alcohols being formed in a highly efficient manner. Catalyst recovery by simple extraction techniques and subsequent reuse has been performed.
Enzymatic enantioselective aldol reactions of isatin derivatives with cyclic ketones under solvent-free conditions
Liu, Zhi-Qiang,Xiang, Zi-Wei,Shen, Zhou,Wu, Qi,Lin, Xian-Fu
, p. 156 - 160 (2014/05/06)
Nuclease p1 from Penicillium citrinum was observed to directly catalyze the asymmetric aldol reactions between isatin derivatives and cyclic ketones with high isolated yields (up to 95%) and moderate to good stereoselectivity (dr up to >99/1, ee up to 82%
