857784-97-5

Usage

Uses

Used in Organic Synthesis:
1-Iododibenzo[b,d]furan is used as a reagent for various transformations and reactions in organic synthesis. Its strong electrophilic properties allow for the introduction of iodine-containing functional groups into organic molecules, facilitating the creation of new compounds with potential applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-iododibenzo[b,d]furan is utilized as a building block for the synthesis of biologically active compounds. Its unique structure contributes to the development of new pharmaceuticals with potential therapeutic benefits.
Used in Pharmaceutical Development:
1-Iododibenzo[b,d]furan is also used in the development of new pharmaceuticals. Its reactivity and the ability to form iodine-containing functional groups make it a promising candidate for creating novel drugs with improved efficacy and selectivity.

Upstream product

• 533-58-4 2-Iodophenol 
• 99-65-0 meta-dinitrobenzene 
• 50548-40-8 1-aminodibenzofuran 
• 162607-19-4 dibenzo[b,d]furan-1-yl-boronic acid 

Relevant academic research and scientific papers

Preparation method of 1-iododibenzofuran

The invention provides a preparation method of 1-iododibenzofuran. The preparation method comprises the following steps: adding potassium tert-butoxide, dimethyl ether and cuprous iodide into a firstreactor, stirring the mixture under the protection of nitrogen gas, adding m-dinitrobenzene dissolved with pyridine into a system, then dissolving potassium tert-butoxide and o-iodophenol with dimethyl ether, adding the dissolved mixture into the system, fully reacting under the protection of the nitrogen gas, and separating to obtain 1-nitryldibenzofuran; then adding 1-nitryldibenzofuran into a second reactor, adding ethanol, water, iron powder and ammonium chloride, fully reacting, and separating to obtain 1-aminodibenzofuran; adding the 1-aminodibenzofuran into a third reactor, then addinghydrochloric acid, dropwise adding a sodium nitrite solution and a KI solution, fully reacting, and separating to obtain 1-iododibenzofuran. The preparation method has the beneficial effects of avoidance of carrying out the reactions under an ultralow temperature reaction condition, simple and feasible synthetic method, stable productivity, higher yield and low pollution, and has remarkable advantages on the aspect of batch production.

Metal-free iodination of arylboronic acids and the synthesis of biaryl derivatives

A simple, general and efficient method is developed for the metal-free iodination of arylboronic acids. The protocol uses very cheap molecular iodine as the halide source and potassium carbonate as the base. The method is highly tolerant of various functional groups present in the substrates. Importantly, the iodination strategy can also be applied very effectively in the one-pot, two-step synthesis of biaryl derivatives. Georg Thieme Verlag Stuttgart New York.