857997-91-2

Usage

Uses

Used in Pharmaceutical and Biologically Active Compounds Synthesis:
C-[2-(4-METHOXY-PHENYL)-THIAZOL-4-YL]-METHYLAMINE is used as a key intermediate in the synthesis of various pharmaceuticals and biologically active compounds, leveraging its unique structural features to contribute to the development of new medications.
Used in Drug Development and Medicinal Chemistry Research:
In the field of drug development, C-[2-(4-METHOXY-PHENYL)-THIAZOL-4-YL]-METHYLAMINE is used as a potential candidate for creating new drugs, given its structural attributes and the possibility of exhibiting a range of pharmacological and physiological effects that can be harnessed for therapeutic purposes.
Used in Organic Synthesis:
C-[2-(4-METHOXY-PHENYL)-THIAZOL-4-YL]-METHYLAMINE is utilized in organic synthesis processes, where its chemical properties allow for the creation of a variety of complex organic molecules that can be applied in different industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 3424-93-9 4-methoxyphenylacetamide 

Relevant academic research and scientific papers

Design, synthesis, DFT study and antifungal activity of the derivatives of pyrazolecarboxamide containing thiazole or oxazole ring

Pyrazolecarboxamide fungicides are one of the most important classes of agricultural fungicides, which belong to succinodehydrogenase inhibitors (SDHIS). To discover new pyrazolecarboxamide analogues with broad spectrum and high activity, a class of new compounds of pyrazole carboxamide derivatives containing thiazole or oxazole ring were designed by scaffold hopping and bioisosterism, and 36 pyrazole carboxamide derivatives with antifungal activity were synthesized. Those compounds were evaluated against five phytopathogenic fungi, Gibberella zeae, Phytophythora capsici, Sclerotonia sclerotiorum, Erysiphe graminis and Puccinia sorghi. The results indicated that most of the compounds displayed good fungicidal activities, especially against E. graminis. Theoretical calculations were carried out at the B3LYP/6-31G (d, p) level and the full geometry optimization was carried out using the 6-31G (d, p) basis set, and the frontier orbital energy, atomic net charges, molecular docking were discussed, and the structure-activity relationships were also studied.