858027-20-0Relevant articles and documents
Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy
Zeng, Zhao-Sen,He, Qiu-Qin,Liang, Yong-Hong,Feng, Xiao-Qing,Chen, Fen-Er,Clercq, Erik De,Balzarini, Jan,Pannecouque, Christophe
experimental part, p. 5039 - 5047 (2010/09/05)
Molecular hybridization of the known anti-HIV-1 template DPC083 and etravirine based on docking model overlay has been generated a novel series of diarylbenzopyrimidine analogues (DABPs) (5a-z). These new hybrids were assessed for their activity against HIV in MT-4 cell cultures. Most of these compounds showed good activity against wild-type HIV-1 and mutant viruses. In particular, compound 5r showed the most potent activity against wild-type HIV-1 with an EC50 value of 1.8 nM, and with a selectivity index up to 111,954. It also proved more active against mutant L100I, K103N, Y188L, and K103N + Y181C RT HIV-1 strains than efavirenz.
Synthesis and evaluation on anticonvulsant and antidepressant activities of 5-alkoxy-tetrazolo[1,5-a]quinazolines
Wang, Huo-Jian,Wei, Cheng-Xi,Deng, Xian-Qing,Li, Fu-Lan,Quan, Zhe-Shan
experimental part, p. 671 - 675 (2010/07/06)
Several 5-alkoxy-tetrazolo[1,5-a]quinazoline derivatives have been synthesized by reacting 2,4-dichloroquinazoline with various phenols or aliphatic alcohol and then with sodium azide. The structures of these compounds have been confirmed by IR, MS,
