85803-49-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Thiophen-2-yl-piperazin is used as a pharmacological agent for its antipsychotic, antidepressant, and anxiolytic effects, targeting the treatment of psychological disorders. Its interaction with serotonin receptors makes it a promising candidate for further development in this area.
Used in Oncology Research:
In the field of oncology, 2-thiophen-2-yl-piperazin is used as a potential anticancer agent. Its demonstrated ability to inhibit cancer cell growth suggests that it could be a valuable compound in the development of new cancer therapies.
Used in Medicinal Chemistry Research:
2-Thiophen-2-yl-piperazin is utilized in medicinal chemistry for its potential to contribute to the discovery of new drugs. Its diverse pharmacological activities and interactions with biological targets make it a valuable tool for research aimed at understanding and treating various diseases.

InChI:InChI=1/C8H12N2S/c1-2-8(11-5-1)7-6-9-3-4-10-7/h1-2,5,7,9-10H,3-4,6H2

Upstream product

• 51445-63-7 oxo-thiophen-2-yl-acetaldehyde 
• 1172227-73-4 2-thienylglyoxal hydrate 
• 56421-72-8 2-(thiophen-2-yl)pyrazine 

Downstream Products

• 85803-50-5 ethyl 3-(2-thienyl)piperazine-1-carboxylate 
• 85803-55-0 1-(2-carbethoxyphenyl)-4-methyl-2-(2-thienyl)piperazine 
• 85803-52-7 1-methyl-3-(2-thienyl)piperazine 
• 85803-54-9 1-<2-(4,4-dimethyl-1,3-oxazolin-2-yl)phenyl>-4-methyl-2-(2-thienyl)piperazine 
• 85803-57-2 1-<2-(hydroxymethyl)phenyl>-4-methyl-2-(2-thienyl)piperazine 

Relevant academic research and scientific papers

ANTAGONISTS OF GPR39 PROTEIN

Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.

7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

7-(substituted)piperazinyl-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acids, the pharmacologically acceptable salts thereof, compositions containing them, processes and intermediates for producing them, and methods of using them to treat bacterial infections in warm-blooded animals.

Tetracyclic heterocycles and antidepressant compositions thereof

Tetracyclic heterocycles of the formula STR1 wherein Th is the residue completing a fused thiophen ring, X represents oxo, hydroxyl together with hydrogen, or preferably two hydrogens, R1 represents lower alkyl, lower alkoxy, chloro, bromo, trifluoromethyl or, preferably, hydrogen, and R2 represents hydroxy-lower alkyl, aryl-lower alkyl, or, preferably, lower alkyl, especially methyl, or hydrogen, and therapeutically acceptable acid addition salts thereof are especially useful as antidepressants, in particular in the form of appropriate pharmaceutical compositions. They are obtainable by conventional synthetic methods of organic chemistry.

Synthesis and biological properties of thiophene ring analogues of mianserin.

The synthesis of two thiophene-containing analogues of mianserin, i.e., 1,2,3,4,10,13b-hexahydro-2-methylpiperazino[1,2-a]thieno[2, 3-c][1]benzazepine (2), and the corresponding [3,2-c] isomer (12) is described. The key step in the synthesis is the nucleo