85803-54-9

Upstream product

• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 85803-52-7 1-methyl-3-(2-thienyl)piperazine 
• 85803-49-2 2-(thien-2-yl)-piperazine 
• 51445-63-7 oxo-thiophen-2-yl-acetaldehyde 
• 85803-50-5 ethyl 3-(2-thienyl)piperazine-1-carboxylate 

Downstream Products

• 85803-57-2 1-<2-(hydroxymethyl)phenyl>-4-methyl-2-(2-thienyl)piperazine 
• 85803-55-0 1-(2-carbethoxyphenyl)-4-methyl-2-(2-thienyl)piperazine 

Relevant academic research and scientific papers

Tetracyclic heterocycles and antidepressant compositions thereof

Tetracyclic heterocycles of the formula STR1 wherein Th is the residue completing a fused thiophen ring, X represents oxo, hydroxyl together with hydrogen, or preferably two hydrogens, R1 represents lower alkyl, lower alkoxy, chloro, bromo, trifluoromethyl or, preferably, hydrogen, and R2 represents hydroxy-lower alkyl, aryl-lower alkyl, or, preferably, lower alkyl, especially methyl, or hydrogen, and therapeutically acceptable acid addition salts thereof are especially useful as antidepressants, in particular in the form of appropriate pharmaceutical compositions. They are obtainable by conventional synthetic methods of organic chemistry.

Synthesis and biological properties of thiophene ring analogues of mianserin.

The synthesis of two thiophene-containing analogues of mianserin, i.e., 1,2,3,4,10,13b-hexahydro-2-methylpiperazino[1,2-a]thieno[2, 3-c][1]benzazepine (2), and the corresponding [3,2-c] isomer (12) is described. The key step in the synthesis is the nucleo