85805-93-2Relevant academic research and scientific papers
Enzymatic Preparation of Optically Active α- and β-Hydroxy Carboxylic Acid Derivatives
Kanerva, Liisa T.,Sundholm, Oskari
, p. 823 - 825 (2007/10/02)
The lipase PS-catalysed resolutions of mandelonitrile (1) and methyl and ethyl hydroxy carboxylates 2-5 have been performed using (PrCO)2O, PrCO2CH=CH2 and PrCO2CH2CF3 as achiral reagents in THF and toluene.High enantioselectivity (e.e. close to 100percent) was observed, especially when butyric anhydride was used as an acylating reagent for the secondary HO group of 2-5. The acylation using PrCO2CH2CF3 was impractical owing to the slow reaction rate.In the acylation of 1 enentioselectivity was only moderate.
1H and 2H Nuclear Magnetic Resonance Determination of the Enantiomeric Purity and Absolute Configuration of α-Deuteriated Primary Carboxylic Acids, Alcohols, and Amines
Parker, David
, p. 83 - 88 (2007/10/02)
The enentiomeric composition and absolute configuration of α-deuteriated primary carboxylic acids may be accurately determined by 1H and 2H nuclear magnetic resonance analysis of the corresponding esters of (S)-methyl 2-hydroxy-2-phenylethanoate (2).Simil
