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858126-78-0

DNP-PEG4-NHS ester is a PEGylated compound that features a DNP moiety and an NHS ester terminal group. The DNP component is known for its role in biological applications, such as facilitating ion transport across membranes. The NHS ester terminal allows for the formation of stable amide bonds with primary amines, while the hydrophilic PEG linkers enhance the compound's solubility in aqueous environments.

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  • 2,5-dioxopyrrolidin-1-yl 1-[(2,4-dinitrophenyl)amino]-3,6,9,12-tetraoxapentadecan-15-oate

    Cas No: 858126-78-0

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  • 858126-78-0 Structure

  • Basic information

    1. Product Name: DNP-PEG4-NHS ester
    2. Synonyms: DNP-PEG4-NHS ester;DNP-PEG4-NHS
    3. CAS NO:858126-78-0
    4. Molecular Formula: C21H28N4O12
    5. Molecular Weight: 528.46662
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 858126-78-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: DNP-PEG4-NHS ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: DNP-PEG4-NHS ester(858126-78-0)
    11. EPA Substance Registry System: DNP-PEG4-NHS ester(858126-78-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 858126-78-0(Hazardous Substances Data)

858126-78-0 Usage

Uses

Used in Bioconjugation:
DNP-PEG4-NHS ester is used as a bioconjugation agent for attaching biomolecules to various surfaces or other molecules. The NHS ester terminal group reacts with primary amines, enabling the formation of stable amide bonds that facilitate the attachment process.
Used in Drug Delivery Systems:
In the pharmaceutical industry, DNP-PEG4-NHS ester is used as a component in drug delivery systems. The PEGylation provided by DNP-PEG4-NHS ester can improve the solubility, stability, and circulation time of drug molecules, potentially enhancing their therapeutic efficacy and reducing side effects.
Used in Diagnostic Imaging:
DNP-PEG4-NHS ester is utilized in diagnostic imaging as a means to attach imaging agents to targeting biomolecules. The stable amide bond formation allows for the creation of conjugates that can be used to enhance the visibility of specific biological structures or processes during imaging procedures.
Used in Biosensor Development:
In the field of biosensors, DNP-PEG4-NHS ester is employed as a component in the development of sensors that require the attachment of recognition elements to transducing surfaces. The PEG linker and NHS ester terminal group facilitate the stable immobilization of these elements, improving sensor performance and reliability.
Used in Membrane Technology:
DNP-PEG4-NHS ester is used in membrane technology as a component for modifying membrane surfaces. The DNP moiety's involvement in ion transport can be leveraged to create membranes with specific selectivity or transport properties, which can be useful in various separation or filtration processes.

Check Digit Verification of cas no

The CAS Registry Mumber 858126-78-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,8,1,2 and 6 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 858126-78:
(8*8)+(7*5)+(6*8)+(5*1)+(4*2)+(3*6)+(2*7)+(1*8)=200
200 % 10 = 0
So 858126-78-0 is a valid CAS Registry Number.

858126-78-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,5-Pyrrolidinedione, 1-[3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-oxopropoxy]-

1.2 Other means of identification

Product number -
Other names DNP-NH-PEG(4)-NHS 1-(2,4-DINITROPHENYLAMINO)-3,6,9,12-TETRAOXAPENTADECANOIC ACID SUCCINIMIDYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:858126-78-0 SDS

858126-78-0Downstream Products

858126-78-0Relevant articles and documents

REAGENTS FOR THIOL CONJUGATION AND CONJUGATES FORMED THEREFROM

-

Paragraph 0048, (2016/02/29)

Reagents for preparing stabilized thioethers for in vivo administration are disclosed, along with said thioethers thus prepared.

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