858130-55-9

Upstream product

• 133673-62-8 4-methyl-benzenesulfonic acid [(2S)-2-hydroxy-3,3-dimethyl-butyl]ester 
• 1472104-43-0 N-[(3R)-3-hydroxy-4,4-dimethyl-pentyl]-carbamic acid tert-butyl ester 
• 31612-63-2 (2S)-3,3-dimethylbutane-1,2-diol 
• 21641-92-9 (S)-2-hydroxy-3,3-dimethylbutanoic acid 
• 59997-51-2 trimethylacetylacetonitrile 

Downstream Products

• 1472103-93-7 2-cyclopropyl-N-[(3R)-3-hydroxy-4,4-dimethyl-pentyl]-6-methyl-4-morpholin-4-yl-benzamide 
• 858130-65-1 N-(3-hydroxy-4,4-dimethyl-pentyl)benzamide 

Relevant academic research and scientific papers

SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS

The invention relates to substituted 4-aminobenzamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS

Substituted 4-aminobenzamides, pharmaceutical compositions containing these compounds and also methods of using these compounds in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Polymer-supported chiral sulfonamide catalyzed one-pot reduction of β-keto nitriles: A practical synthesis of (R)-fluoxetine and (R)-duloxetine

Enantioselective reduction of β-keto nitriles to optically active 1,3-amino alcohols has been carried out in one step using an excess of borane-dimethyl sulfide complex as a reductant and a polymer-supported chiral sulfonamide as a catalyst with moderate to high enantioselectivity. The facile and enantioselective method to prepare optically active 1,3-amino alcohols to be converted into 3-aryloxy-3-arylpropylamine-type antidepressant drugs (R)-fluoxetine, and (R)-duloxetine is also reported.