85817-60-3

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE is used as an antifungal agent for its potential to combat fungal infections. Its unique structure, featuring chloro and methyl groups, contributes to its antifungal properties, making it a valuable compound in the development of new antifungal medications.
Used in Neurological Disorder Treatment:
2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE is also being studied for its potential use in the treatment of various neurological disorders. 2-CHLORO-N-(5-CHLORO-2-METHYL-PHENYL)-ACETAMIDE's specific structural features may offer therapeutic benefits in managing or treating such conditions, although further research is needed to fully understand its applications in this area.

InChI:InChI=1/C9H9Cl2NO/c1-6-2-3-7(11)4-8(6)12-9(13)5-10/h2-4H,5H2,1H3,(H,12,13)

Upstream product

• 95-79-4 5-chloro-2-methyl-benzenamine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 500345-88-0 N-(5-chloro-2-methylphenyl)-2-(ethylamino)acetamide 
• 332912-24-0 C₂₈H₂₂ClN₃O₂S 
• 919422-91-6 C₁₆H₁₄ClN₅O 
• 937862-11-8 C₁₆H₁₄ClN₅O 
• 110063-03-1 1-[(5-chloro-2-methyl-phenylcarbamoyl)-methyl]-pyridinium; chloride 
• 332909-18-9 piperidino-acetic acid-(5-chloro-2-methyl-anilide) 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors

Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2′-dithiobis(N-(2-fluorophenyl)acetamide) (d7), 2,2′-dithiobis(N-(3,5-difluorophenyl)acetamide) (d24), and 2,2′-dithiobis(N-(3-fluorophenyl)acetamide) (d8) were here identified as the most active inhibitors with IC50 of 0.074, 0.44, and 0.81 μM, showing 32- to 355-fold higher potency than the positive control acetohydroxamic acid. These disulfides were confirmed to bind urease without covalent modification of the cysteine residue and to inhibit urease reversibly with a mixed inhibition mechanism. They also showed very good anti-Helicobacter pylori activities with d8 showing a comparable potency to the clinical used drug amoxicillin. The impressive in vitro biological profile indicated their immense potential as therapeutic agents to tackle H. pylori caused infections.

Facile synthesis and antifungal activity of dithiocarbamate derivatives bearing an amide moiety

Two series of novel dithiocarbamate derivatives bearing an amide moiety, 3a-i and 4a-i, were synthesized by a facile method, and the structures of the derivatives were confirmed by elemental analysis and 1H-NMR, 13C- -NMR and high-resolution mass spectrometry (HRMS). Their antifungal activity against five phytopathogenic fungi were evaluated, and the results showed that most of the target compounds displayed low antifungal activity in vitro against Gibberella zeae, Cytospora sp., Colletotrichum gloeosporioides, Alternaria solani, and Fusarium solani at a concentration of 100 mg L-1. However, two compounds, 4f and 4g, exhibited significant activity against A. solani and C. gloeosporioides, respectively.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia

Novel N-aryl-piperazinealkanamides, having particular substituents attached to one of the carbon atoms of the piperazine ring, which compounds are useful to protect hearts from myocardial injury caused by ischaemia, anoxia or hypoxia.