85841-92-5Relevant academic research and scientific papers
Camoform analogs as potential agents against mefloquine resistant malaria
Hung,Werbel
, p. 61 - 66 (2007/10/02)
Analogs of 5,5'-di-2-propenyl-3,3'-bis(1-pyrrolidinylmethyl) [1,1'-biphenyl]-4,4'-diol 2 which exhibited modest activity against chloroquine- and mefloquine-resistant lines of Plasmodium berghei were prepared. Modifications of the Mannich side chain, the propenyl group, and analogs wherein a bridging atom was inserted between the phenyl rings were prepared. None of the structural changes provided an improvement in antimalarial activity over the lead compound in the P. berghei mouse system.
