858466-68-9

Basic information

• Product Name: Quinoline, 4-acetamido-5,6,7,8-tetrahydro- (5CI)
• Synonyms: Quinoline, 4-acetamido-5,6,7,8-tetrahydro- (5CI)
• CAS NO: 858466-68-9
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.24166
• Mol File: 858466-68-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Quinoline, 4-acetamido-5,6,7,8-tetrahydro- (5CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 4-acetamido-5,6,7,8-tetrahydro- (5CI)(858466-68-9)
• EPA Substance Registry System: Quinoline, 4-acetamido-5,6,7,8-tetrahydro- (5CI)(858466-68-9)

Safety Data

• Hazardous Substances Data: 858466-68-9(Hazardous Substances Data)

Upstream product

• 1198-40-9 4-amino-7-chloroquinoline 
• 86-98-6 4,7-dichloroquinoline 

Downstream Products

• 133092-34-9 4-chloro-5,6,7,8-tetrahydroquinoline 

Relevant articles and documents

Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Mice

In this Letter, a detailed analysis of 30 4-aminoquinoline-based compounds with regard to their potential as antileishmanial drugs has been carried out. Ten compounds demonstrated IC50 50 1 μM against intramacrophage L. infantum amastigotes. Two compounds showed dose-dependent enhancement of NO and ROS production by bone marrow-derived macrophages and remarkable reduction of parasite load in vivo, with advantage of being short-term and orally active. To the best of our knowledge, this is the first example of 4-amino-7-chloroquinoline derivatives active in Leishmania infantum infected mice.