85847-89-8

Basic information

• Product Name: Butanoic acid, 2-fluoro-3-Methyl-, ethyl ester
• Synonyms: Butanoic acid, 2-fluoro-3-Methyl-, ethyl ester
• CAS NO: 85847-89-8
• Molecular Formula: C₇H₁₃FO₂
• Molecular Weight: 148.1753232
• Mol File: 85847-89-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Butanoic acid, 2-fluoro-3-Methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-fluoro-3-Methyl-, ethyl ester(85847-89-8)
• EPA Substance Registry System: Butanoic acid, 2-fluoro-3-Methyl-, ethyl ester(85847-89-8)

Safety Data

• Hazardous Substances Data: 85847-89-8(Hazardous Substances Data)

Upstream product

• 13893-45-3 valine ethyl ester 
• 125950-65-4 2-(Diisopropoxy-phosphoryl)-2-fluoro-3-methyl-butyric acid ethyl ester 
• 516-06-3 D,L-valine 

Relevant articles and documents

Alkylation of (Fluorocarbethoxymethylene)-tri-n-butylphosphorane: A Facile Entry to α-Fluoroalkanoates

(Fluorocarbethoxymethyl)trialkylphosphonium bromides 6, prepared from ethyl bromofluoroacetate and tertiary phosphines, react with n-butyllithium in THF to give the corresponding phosphoranes 7.Reaction of the pregenerated (fluorocarbethoxymethylene)tri-n-butylphosphorane 7a with primary alkyl iodides and activated alkyl bromides followed by in situ hydrolysis of the alkylated salts provides the fluoroalkanoates 9 in a one-pot reaction.In the case of secondary alkyl halides, no substitution was observed, the main reaction being decomposition of the phosphorane.However, the anion obtained from diisopropyl (fluorocarbethoxymethyl)phosphonate 10 b reacts with CH3CH(Ph)Br and (CH3)2CHI to afford the corresponding alkylated phosphonates in good yields.Displacement of the phosphonate moiety either by base-induced hydrolysis or by reduction was unsuccessful.