85849-33-8 Usage
Uses
Used in Pharmaceutical Synthesis:
(+)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(2-METHYLPHENYL)PHOSPHINO]BUTANE is used as a chiral ligand in pharmaceutical synthesis for its ability to selectively bind with transition metals and facilitate enantioselective transformations. This selective binding is crucial for the production of enantiomerically pure compounds, which are essential in the development of effective and safe drugs.
Used in Material Science:
In the field of material science, (+)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(2-METHYLPHENYL)PHOSPHINO]BUTANE is used as a chiral ligand for the synthesis of advanced materials with specific properties. Its ability to selectively bind with transition metals allows for the creation of materials with tailored characteristics, such as chiral polymers and catalysts, which can be used in various applications, including sensors, catalysts, and chiral separation techniques.
Used in Asymmetric Catalytic Reactions:
(+)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(2-METHYLPHENYL)PHOSPHINO]BUTANE is used as a chiral ligand in various asymmetric catalytic reactions, such as hydrogenation, hydroformylation, and allylic alkylation. Its complex structure and functional groups enable it to selectively bind with transition metals, promoting enantioselective transformations and leading to the production of chiral compounds with high enantiomeric purity. This is particularly important in the synthesis of pharmaceuticals and agrochemicals, where the enantiomeric composition of a compound can significantly impact its biological activity and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 85849-33-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,8,4 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 85849-33:
(7*8)+(6*5)+(5*8)+(4*4)+(3*9)+(2*3)+(1*3)=178
178 % 10 = 8
So 85849-33-8 is a valid CAS Registry Number.
85849-33-8Relevant academic research and scientific papers
Rhodium-Catalyzed Enantioselective Radical Addition of CX4 Reagents to Olefins
Chen, Bo,Fang, Cheng,Liu, Peng,Ready, Joseph M.
supporting information, p. 8780 - 8784 (2017/07/17)
We describe the synthetically useful enantioselective addition of Br?CX3 (X=Cl or Br) to terminal olefins to introduce a trihalomethyl group and generate optically active secondary bromides. Computational and experimental evidence supports an asymmetric atom-transfer radical addition (ATRA) mechanism in which the stereodetermining step involves outer-sphere bromine abstraction from a [(bisphosphine)RhIIBrCl] complex by a benzylic radical intermediate. This mechanism appears unprecedented in asymmetric catalysis.
