858515-66-9 Usage
General Description
1H-Indole-3-carboxylic acid, 7-fluoro is a chemical compound with the molecular formula C9H6FNO2. It is a derivative of indole, a heterocyclic organic compound commonly found in plant-based materials. This particular derivative is characterized by the presence of a fluorine atom, which imparts unique chemical properties to the molecule. 1H-Indole-3-carboxylic acid, 7-fluoro is used in the synthesis of various pharmaceutical and agrochemical products, and it has potential applications in medicinal chemistry. As a fluorinated indole derivative, it may exhibit altered pharmacokinetic and biological activities compared to its non-fluorinated counterparts, making it an interesting target for further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 858515-66-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,8,5,1 and 5 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 858515-66:
(8*8)+(7*5)+(6*8)+(5*5)+(4*1)+(3*5)+(2*6)+(1*6)=209
209 % 10 = 9
So 858515-66-9 is a valid CAS Registry Number.
858515-66-9Relevant articles and documents
METHODS OF TREATING CANCER
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Paragraph 00206-00207, (2020/06/10)
The present disclosure relates to methods of treating cancer in a patient using a combination of an inhibitor of an immune checkpoint protein and an indole compound or its phosphate derivative.
Design, synthesis and structure-activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate
Ratcliffe, Paul,Adam, Julia M.,Baker, James,Bursi, Roberta,Campbell, Robert,Clark, John K.,Cottney, Jean E.,Deehan, Maureen,Easson, Anna-Marie,Ecker, Daniel,Edwards, Darren,Epemolu, Ola,Evans, Louise,Fields, Ruth,Francis, Stuart,Harradine, Paul,Jeremiah, Fiona,Kiyoi, Takao,McArthur, Duncan,Morrison, Angus,Passier, Paul,Pick, Jack,Schnabel, Peter G.,Schulz, Jurgen,Steinbrede, Heinz,Walker, Glenn,Westwood, Paul,Wishart, Grant,Haes, Joanna Udo De
scheme or table, p. 2541 - 2546 (2011/06/17)
We report an expansion of the structure-activity relationship (SAR) of a novel series of indole-3-heterocyclic CB1 receptor agonists. Starting from the potent but poorly soluble lead, 1, a rational approach was taken in order to balance solubility, hERG a
