85864-09-1

Basic information

• Product Name: 6-cyano-1H-indole-2-carboxylic acid
• Synonyms: 6-cyano-1H-indole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 6-cyano-
• CAS NO: 85864-09-1
• Molecular Formula: C₁₀H₆N₂O₂
• Molecular Weight: 186.16684
• EINECS: -0
• Mol File: 85864-09-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-cyano-1H-indole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-cyano-1H-indole-2-carboxylic acid(85864-09-1)
• EPA Substance Registry System: 6-cyano-1H-indole-2-carboxylic acid(85864-09-1)

Safety Data

• Hazardous Substances Data: 85864-09-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-cyano-1H-indole-2-carboxylic acid is used as a key intermediate for the synthesis of various drugs and pharmaceuticals. Its unique chemical structure and properties make it a valuable building block for the production of a wide range of important organic compounds.
Used in Drug Development for Cancer Treatment:
6-cyano-1H-indole-2-carboxylic acid is used as a precursor in the development of drugs for the treatment of various types of cancer. Its chemical properties allow for the creation of compounds that can target and treat cancer cells effectively.
Used in Drug Development for Neurological Disorders:
6-cyano-1H-indole-2-carboxylic acid is also used in the development of drugs for the treatment of neurological disorders. Its structure and properties enable the synthesis of compounds that can potentially alleviate symptoms and improve the quality of life for patients suffering from such conditions.

Upstream product

• 104291-83-0 6-Cyanindol-2-carbonsaeure-methylester 
• 104-85-8 para-methylbenzonitrile 
• 105191-34-2 3-(4-cyano-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester 
• 939-79-7 4-cyano-2-nitrotoluene 
• 104291-81-8 ethyl 6-cyano-1H-indole-2-carboxylate 

Downstream Products

• 199609-40-0 6-(Benzyloxycarbonylamino-imino-methyl)-1H-indole-2-carboxylic acid 
• 259150-24-8 tert-butyl trans-[4-(6-amidinoindole-2-carboxamido)cyclohexyloxy]acetate 
• 174775-27-0 {4-[(6-cyano-1H-indole-2-carbonyl)-amino]-cyclohexyloxy}-acetic acid tert-butyl ester 
• 15861-36-6 1H-Indole-6-carbonitrile 
• 147920-12-5 1-[(6-cyano-2-indolyl)carbonyl]-4-[3-(isopropylamino)-2-pyridinyl]piperazine 

Relevant articles and documents

POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS

The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

MATRIPTASE 2 INHIBITORS AND USES THEREOF

The present invention provides compounds for inhibiting matriptase 2, or a mutant thereof, and compositions and methods of use thereof.

N-CYCLYL-3 - (CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS

The present invention relates to compounds of formula (I) : and pharmaceutically acceptable salts thereof, wherein R1and R2 are various ring systems. The invention also relates to pharmaceutical compositions comprising these compound

PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS

The invention relates to annelated phenyl piperazine and phenyl diazepane carboxamides of general formula (I) containing oxygen.The compounds are suitable for medical purposes.

Preparation and pharmacological evaluation of novel glycoprotein (Gp) IIb/IIIa antagonists. 2. Condensed heterocyclic derivatives

A novel series of platelet receptor glycoprotein (Gp) IIb/IIIa antagonists with condensed heterocycles as their basic core was synthesized. In an in vitro assay, trans-4-(5-amidinobenzofuran-2- carboxamido)cyclohexyl]oxyacetic acid 17e and trans-3-[4-(5-

Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists

The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa) antagonists is described. The additional conformational restriction offered by the bicyclic nucleus results in 20-400-fold increases in potency compared to the freely flexible, acyclic benzamidine counterpart. The design, synthesis, structure-activity relationships (SAR), and in vitro activity of this novel class of GPIIb-IIIa antagonists are presented.

5,6-Bicyclic glycoprotein IIb IIIa antagonists useful in inhibition of platelet aggregation

This invention relates to 5,6 fused ring bicyclic compounds inclusive of indoles, benzofurans, and benzothiophenes, and corresponding to the formula (I) substituted with both basic (B) and acidic (A) functionality, which are useful in inhibition of platelet aggregation.