85864-33-1

Usage

Chemical Properties

white powder

InChI:InChI=1/C18H21NO/c1-18(2,3)17(20)19-16-12-8-7-11-15(16)13-14-9-5-4-6-10-14/h4-12H,13H2,1-3H3,(H,19,20)

Upstream product

• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 28059-64-5 2-benzylaniline 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 910620-62-1 1-(2-(2-methoxy)tetrahydrofuranyl)-2-phenyl-2-(2-pivaloylamidophenyl)ethanone 
• 87091-13-2 1-(2-(5-methoxy)furanyl)-2-phenyl-2-(2-pivaloylamodidiphenyl)ethanone 
• 85864-34-2 1,2-diphenyl-2-(pivaloylamidophenyl)ethanol 
• 901130-14-1 2'-(3-methoxycarbonyl-1,2-diphenylpropyl)-2,2-dimethylpropioanilide 
• 923984-36-5 (R)-tert-butyl 3-{2-[(2,2-dimethylpropanoyl)amino]phenyl}-3-phenylpropanoate 
• 85852-08-0 methyl 2-phenyl-2-(2-pivaloylamidophenyl)acetate 
• 87091-18-7 2-(2-furanyl)-3-phenyl-1-pivaloylindoline 
• 85852-09-1 2-phenyl-2-(2-pivaloylamidophenyl)pent-4-enoic acid 
• 85852-12-6 α-phenyl-α-(2-pivaloylamidophenyl)-γ-butyrolactone 
• 87091-08-5 1-(2-furanyl)-2-phenyl-2-(2-pivaloylamidophenyl)ethanone 
• 85852-23-9 methyl 1,4-dihydro-4-phenyl-1-pivaloyl-4-quinolinecarboxylate 

Relevant academic research and scientific papers

Design and synthesis of C2-symmetric N-heterocyclic carbene precursors and metal carbenoids

Chiral, C2-symmetric imidazolium and imidazolinium ions, as well as the corresponding copper- or silver-bound carbenoids, have been prepared. Structural study of these compounds by X-ray crystallography reveals a chiral pocket that surrounds th

Pd-catalyzed intermolecular ortho-C-H amidation of anilides by N-nosyloxycarbamate

A palladium-catalyzed ortho-C-H amidation of anilides by N-nosyloxycarbamates was developed for the synthesis of 2-aminoanilines. This reaction can be carried out under relatively mild conditions and exhibits excellent regioselectivity and functional group tolerance. The amidation reaction is probably initiated by rate-limiting C-H cyclopalladation (k H/kD = 3.7) to form an arylpalladium complex, followed by nitrene functionalization.

Synthetic approaches to haplophytine. 1. Synthesis of 1-methoxy- and 1-hydroxy-6-phenyl-6-(2-pivaloylamidophenyl)non-8-ene-4,5-dione and 1-methyl-3-phenyl-3-(pivaloylamidophenyl)-2-pyrrolidinone

An analysis of the structures of the alkaloid haplophytine and its dihydrobromide which is formed with rearrangement, shows that they are both derived from a 7-(2-amino-3-hydroxyphenyl)-7-aryl-9-(methylamino)-5,6-dioxonoanoic acid moiety (3).Approaches to the synthesis of compounds related to 3 are described.The dianion 13 of phenyl(2-pivaloylamidophenyl)methane, that of methyl 2-phenyl-2-(2-pivaloylamidophenyl)acetate, and the trianion 37 of 2-phenyl-2-(2-pivaloylamidophenyl)acetic acid undergo C-alkylation and C-acylation with nucleophiles.Acylation of 13 with methyl 2,2,5-trimethoxypentanoate followed by hydrolysis gives 6-methoxy-1-phenyl-1-(2-pivaloylamidophenyl)-2,3-hexanedione.This with allyl bromide and sodium carbonate gives O-allyl derivative, which on thermolysis is converted to its C-allyl isomer, 1-methoxy-6-phenyl-6-(2-pivaloylamidophenyl)non-8-ene-4,5-dione.The corresponding 1-hydroxy compound was prepared analogously via acylation of 13 with methyl tetrahydro-2-methoxyfuran-2-carboxylate.C-allylation of trianion 37 gives 2-phenyl-2-(2-pivaloylamidophenyl)pent-4-enoic acid, whose methyl ester on ozonolysis followed by treatment with methylamine hydrochloride and sodium cyanoborohydride gives 1-methyl-3-phenyl-3-(2-pivaloylamidophenyl)-2-pyrrolidinone, a potential advanced intermediate for the synthesis of compounds related to 3.