858675-87-3Relevant academic research and scientific papers
Dynamic combinatorial libraries of disulfide cages in water
West, Kevin R.,Bake, Kyle D.,Otto, Sijbren
, p. 2615 - 2618 (2005)
(Figure Presented) Dynamic combinatorial libraries (DCLs) containing water-soluble disulfide-linked cages (alongside macrocyclic structures) have been generated and characterized. Unlike most other strategies for generating molecular cages, the structures are held together by covalent bonds, which are formed under thermodynamic control. The diversity of the cages generated opens new possibilities for a generalized combinatorial strategy toward molecular encapsulation.
Structural self-sorting of pseudopeptide homo and heterodimeric disulfide cages in water: mechanistic insights and cation sensing
Konopka, Marcin,Cecot, Piotr,Harrowfield, Jack M.,Stefankiewicz, Artur R.
, p. 7607 - 7614 (2021)
The molecular components of biological systems self-sortviadifferent mechanisms to act in a cooperative manner and to avoid interfering with each other. Herein we describe mechanistic insights and a versatile strategy for the synthesis of water-soluble, pseudopeptide molecular cages based on disulfide bonds. The use of trifunctional thiols led to a dynamic combinatorial library (DCL) of readily isolable, multi-component homo and hetero cage-like architectures showing a degree of self-sorting related to the symmetry and size of the trithiol. The work provided detailed kinetic studies and DFT molecular modeling giving original insights into the disulfide cages' properties. We also applied the selected cage system in the fluorometric detection of La3+cations, which led to the generation of a strongly luminescent metal-organic assembly.
