858679-83-1

Upstream product

• 121-86-8 2-chloro-4-nitrotoluene 
• 85544-62-3 1-dimethylamino-2-(2'-chloro-4'-nitrophenyl)-ethylene 
• 69395-15-9 2-(2-chloro-4-nitro-phenyl)-ethanol 
• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 73088-10-5 2-(2-chloro-4-nitro-phenyl)-malonic acid dimethyl ester 

Downstream Products

• 1349744-18-8 [2-(2-chloro-4-nitro-phenyl)-ethyl]-(4-fluoro-benzyl)-amine 
• 1349744-20-2 [2-(2-chloro-4-nitro-phenyl)-ethyl]-(4-fluoro-benzyl)-carbamic acid tert-butyl ester 
• 1349744-23-5 [2-(4-amino-2-chloro-phenyl)-ethyl]-(4-fluoro-benzyl)-carbamic acid tert-butyl ester 
• 1349744-24-6 (2-{2-chloro-4-[3-(5-cyano-pyrazin-2-yl)-ureido]-phenyl}-ethyl)-(4-fluoro-benzyl)-carbamic acid tert-butyl ester 
• 1349742-95-5 1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea 
• 1349744-19-9 N-[2-(2-chloro-4-nitro-phenyl)-ethyl]-(4-fluoro-benzyl)-amine hydrochloride 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOUNDS

The invention provides a compound of the formula (1): or a salt, N-oxide or tautomer thereof; wherein R1 is cyano or C1-4 alkyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 and R5 are the same or different and each is selected from hydrogen, saturated C1-4 hydrocarbyl and saturated C1-4 hydrocarbyloxy; R6 and R7 are the same or different and each is selected from hydrogen, halogen, CN, C1-4 alkyl and C1-4 alkoxy wherein the C1-4 alkyl and C1-4 alkoxy are each optionally substituted with hydroxy, C1-2 alkoxy or by one or more flourine atoms; R8 is hydrogen or C1-4 alkyl; Q is an alkylene chain of 1 to 4 carbon atoms in length between the moiety Ar and the nitrogen atom N, wherein one or more of the 1 to 4 carbon atoms of the alkylene chain may optionally be substituted with one or two C1-4 alkyl groups, or wherein one carbon atom of the 1 to 4 carbon atoms of the alkylene chain may optionally be substituted with a group -CH2CH2- which together with the said one carbon atom forms a cyclopropyl group; m is 1, 2, 3 or 4; n is 0 or 1; and Ar is a monocyclic or bicyclic aryl or heteroaryl group of 5 to 10 ring members containing 0, 1, 2, 3 or 4 heteroatom ring members selected from O, N and S, the aryl or heteroaryl group being optionally substituted with one to four substituents R13 as defined in the claims. The compounds are inhibitors of Chk-1 kinase and are active against cancers.

Facile, environmentally friendly synthesis of benzaldehyde and phenylacetaldehyde analogs from readily available toluene derivatives

A facile environmentally friendly synthesis of bezaldehyde and phenylacetaldehyde analogs from readily available toluene derivatives is described. Oxidation of the styrylamines by H2O2 H2O2 affords benzaldehydes in moderate yields, while the hydrolysis of styrylamines afforded phenylacetaldehyde analogs in good yields. Copyright