73088-10-5

Upstream product

• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 108-59-8 malonic acid dimethyl ester 
• 99-54-7 3,4-dichloronitrobenzene 

Downstream Products

• 404597-47-3 2-(2-chloro-4-nitro-phenyl)-2-(3-oxo-butyl)-malonic acid dimethyl ester 
• 404597-54-2 2-(2-chloro-4-nitro-phenyl)-2-methoxycarbonyl-succinic acid 4-ethyl ester 1-methyl ester 
• 404597-50-8 2-allyl-2-(2-chloro-4-nitro-phenyl)-malonic acid dimethyl ester 
• 404597-59-7 2-(2-chloro-4-nitro-phenyl)-2-methoxycarbonyl-pentanedioic acid dimethyl ester 
• 404597-52-0 2-(2-chloro-4-nitro-phenyl)-2-(2-oxo-2-phenyl-ethyl)-malonic acid dimethyl ester 
• 1437717-28-6 tert-butyl 2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)phenethyl(cyclohexylmethyl)carbamate 
• 1437717-20-8 tert-butyl 2-(4-amino-2-chlorophen)ethyl(cyclohexylmethyl)carbamate 
• 1437717-13-9 tert-butyl 2-(2-chloro-4-nitrophenyl)ethyl(cyclohexylmethyl)carbamate 
• 1437717-05-9 2-(2-chloro-4-nitrophenyl)-N-(cyclohexylmethyl)ethanamine 
• 227467-67-6 1-(2-bromoethyl)-2-chloro-4-nitrobenzene 
• 1349744-19-9 N-[2-(2-chloro-4-nitro-phenyl)-ethyl]-(4-fluoro-benzyl)-amine hydrochloride 
• 1349744-18-8 [2-(2-chloro-4-nitro-phenyl)-ethyl]-(4-fluoro-benzyl)-amine 
• 858679-83-1 2-chloro-4-nitrophenylacetaldehyde 
• 1349742-95-5 1-{3-chloro-4-[2-(4-fluoro-benzylamino)-ethyl]-phenyl}-3-(5-cyano-pyrazin-2-yl)-urea 

Relevant academic research and scientific papers

Pharmaceutically Active Pyrazine Derivatives

The invention provides compounds which inhibit or modulate the activity of Chk-1 kinase and which are useful in the treatment of cancer. The compounds have the general formula (1): and salts, N-oxides and tautomers thereof, wherein m is 2, 3 or 4; n is 0

PHARMACEUTICALLY ACTIVE PYRAZINE DERIVATIVES

The invention provides compounds which inhibit or modulate the activity of Chk-1 kinase and which are useful in the treatment of cancer. The compounds have the general formula (1) and salts, N-oxides and tautomers thereof, wherein m is 2, 3 or 4; n is 0 o

PHARMACEUTICAL COMPOUNDS

The invention provides a compound of the formula (1): or a salt, N-oxide or tautomer thereof; wherein R1 is cyano or C1-4 alkyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 and R5 are the same or different and each is selected from hydrogen, saturated C1-4 hydrocarbyl and saturated C1-4 hydrocarbyloxy; R6 and R7 are the same or different and each is selected from hydrogen, halogen, CN, C1-4 alkyl and C1-4 alkoxy wherein the C1-4 alkyl and C1-4 alkoxy are each optionally substituted with hydroxy, C1-2 alkoxy or by one or more flourine atoms; R8 is hydrogen or C1-4 alkyl; Q is an alkylene chain of 1 to 4 carbon atoms in length between the moiety Ar and the nitrogen atom N, wherein one or more of the 1 to 4 carbon atoms of the alkylene chain may optionally be substituted with one or two C1-4 alkyl groups, or wherein one carbon atom of the 1 to 4 carbon atoms of the alkylene chain may optionally be substituted with a group -CH2CH2- which together with the said one carbon atom forms a cyclopropyl group; m is 1, 2, 3 or 4; n is 0 or 1; and Ar is a monocyclic or bicyclic aryl or heteroaryl group of 5 to 10 ring members containing 0, 1, 2, 3 or 4 heteroatom ring members selected from O, N and S, the aryl or heteroaryl group being optionally substituted with one to four substituents R13 as defined in the claims. The compounds are inhibitors of Chk-1 kinase and are active against cancers.

RAF INHIBITORS

The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of

Improved raf inhibitors

The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Dimethyl malonate as a one-carbon source: A novel method of introducing carbon substituents onto aromatic nitro compounds

A number of carbon substituents possessing various functional groups could be introduced onto aromatic nitro compounds using dimethyl malonate as a one-carbon source and linker. Decarboxylation of both the ester groups originating from dimethyl malonate in this methodology is particularly significant.