858795-19-4Relevant academic research and scientific papers
Selectfluor facilitated bridging of indoles to bis(indolyl)methanes using methyl: Tert -butyl ether as a new methylene precursor
Jin, Jiang,Li, Yinghua,Xiang, Shiqun,Fan, Weibin,Guo, Shiwei,Huang, Deguang
, p. 4076 - 4081 (2021)
A novel, green and efficient method is developed for the synthesis of methylene bridged bis(indolyl)methanes in good to excellent yields. The reaction employs methyl tert-butyl ether (MTBE) as the methylene source and selectfluor as an oxidizing agent. The scope and versatility of the methods have been successfully demonstrated with 48 examples. The metal-free transformation process is suitable for scale-up production. A selectfluor-promoted oxidative reaction mechanism is proposed based on the results of the experimental studies. This journal is
Metal-free synthesis of methylene-bridged bis-1,3-dicarbonyl compounds via oxidative C-C bond cleavage of tertiary aliphatic amines
Xing, Li-Juan,Wang, Xi-Mei,Li, Hong-Ying,Zhou, Wen,Kang, Ning,Wang, Peng,Wang, Bin
, p. 26783 - 26786 (2014/07/21)
A metal-free Bu4NI mediated oxidative reaction utilizing tertiary aliphatic amines and 1,3-dicarbonyl compounds for the synthesis of methylene-bridged bis-1,3-dicarbonyl compounds has been developed. This reaction involved an unexpected C-C bond cleavage of tertiary aliphatic amines. With this approach, the completely regioselective functionalization of β-carbon on tertiary amines was realized. This journal is the Partner Organisations 2014.
