85881-85-2

Basic information

• Product Name: 2-Pyrrolidinone, 1,5-diacetyl- (9CI)
• Synonyms: 2-Pyrrolidinone, 1,5-diacetyl- (9CI)
• CAS NO: 85881-85-2
• Molecular Formula: C₈H₁₁NO₃
• Molecular Weight: 169.17784
• Product Categories: ACETYLGROUP;PYRROLE
• Mol File: 85881-85-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyrrolidinone, 1,5-diacetyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 1,5-diacetyl- (9CI)(85881-85-2)
• EPA Substance Registry System: 2-Pyrrolidinone, 1,5-diacetyl- (9CI)(85881-85-2)

Safety Data

• Hazardous Substances Data: 85881-85-2(Hazardous Substances Data)

Upstream product

• 617-65-2 Glutamic acid 
• 108-24-7 acetic anhydride 
• 56-86-0 L-glutamic acid 
• 6893-26-1 D-Glutamic acid 

Downstream Products

• 85213-22-5 2-acetyl-1-pyrrolidine 
• 85858-23-7 (4RS,5SR)-4-methyl-4-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-2-one 
• 85858-23-7 (4SR,5SR)-4-methyl-4-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-2-one 
• 85858-19-1 5-(1-hydroxy-1-phenylethyl)pyrrolidin-2-one 
• 85858-19-1 5-(1-hydroxy-1-phenylethyl)pyrrolidin-2-one 
• 85858-12-4 (5SR)-5-<(2RS)-2-hydroxy-1-phenylpropan-2-yl>pyrrolidin-2-one 
• 85858-21-5 (S)-1-Phenyl-1-(S)-pyrrolidin-2-yl-ethanol 
• 85858-21-5 (S)-1-Phenyl-1-(R)-pyrrolidin-2-yl-ethanol 
• 85858-09-9 5-acetylpyrrolidin-2-one 

Relevant articles and documents

SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

BICYCLIC AMIDE COMPOUNDS AND METHODS OF USE THEREOF

The invention provides novel compounds having the general formula I: wherein R1, R2, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

METHOD FOR SYNTHESISING 2-ACETYL-1-PYRROLINE AND THE STABLE PRECURSOR THEREOF, OPTIONALLY ISOTOPICALLY MARKED

The present invention relates to a method for synthetizing a compound of the following formula (I): wherein R is a methyl or ethyl group, n is 1 or 2, and X is a CH2 or CD2 group, from a compound of the following formula (II): wherein R and n are as defined above, and also relates to a method for assaying the compounds of the formula (I) using a corresponding deuterated derivative as an internal reference, as well as to the use of ketal derivatives of compounds of the formula (I) as a stable precursor, in particular in a flavoring composition.

Preparation of 5-(1-alkyl-carbonyloxy)alkylpyrrolidin-2-one

The invention is a process for the preparation of a 5-(1-alkylcarbonyloxy)alkylpyrrolidin-2-one which comprises contacting a N-alkylcarbonyl-5-alkylcarbonylpyrrolidin-2-one with hydrogen in the presence of a catalytic amount of a hydrogenation catalyst under conditions such that a 5-(1-alkylcarbonyloxy)alkylpyrrolidin-2-one is prepared.

γ-allenyl-γ-aminobutyric acids

This invention is for γ-allenyl-γ-aminobutyric acid derivatives which are γ-aminobutyric acid transaminase inhibitors.

On the Stereoselectivity of Epoxide Formation using Dimethyloxosulphonium Methylide. X-Ray Structure of (5SR)-5-pyrrolidin-2-one

As background to a proposed dendrobatid toxin 251 D synthesis, the stereoselectivity of epoxide formation from 5-acetylpyrrolidin-2-one (4) and dimethyloxosulphonium methylide was investigated.In THF under 'salt-free' conditions, the major epoxide product, selectivity 78:22, was (5SR)-5-pyrrolidin-2-one (5), whereas addition of anhydrous ZnCl2 to the reaction mixture reversed the stereoselectivity to give epoxides (5) and (6) in the ratio 23:77.Configurations were assigned to these epoxides by comparison of n.m.r. spectra of the derived carbamates (15) and (16), and by an X-ray structure determination for epoxide (6).Related reactions are discussed.