85894-46-8 Usage
General Description
2',5-difluoro-1-arabinosyluridine monophosphate is a chemical compound derived from the nucleoside uridine. It is a modified version of uridine with two fluorine atoms attached at the 2' and 5' positions, and a phosphate group attached to the 1' position of the arabinose sugar. 2',5-difluoro-1-arabinosyluridine monophosphate is a prodrug that is converted into the biologically active antiviral agent, 2',5-difluoro-1-arabinosyluracil, within the body. It has been studied for its potential in the treatment of viral infections, particularly those caused by herpes simplex virus and varicella-zoster virus. It has shown promising antiviral activity in both in vitro and in vivo studies, making it a potential candidate for further drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 85894-46-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,8,9 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 85894-46:
(7*8)+(6*5)+(5*8)+(4*9)+(3*4)+(2*4)+(1*6)=188
188 % 10 = 8
So 85894-46-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H11F2N2O8P/c10-3-1-13(9(16)12-7(3)15)8-5(11)6(14)4(21-8)2-20-22(17,18)19/h1,4-6,8,14H,2H2,(H,12,15,16)(H2,17,18,19)/t4-,5+,6-,8-/m1/s1
85894-46-8Relevant academic research and scientific papers
Coderre, Jeffrey A.,Santi, Daniel V.,Matsuda, Akira,Watanabe, Kyoichi A.,Fox, Jack J.
, p. 1149 - 1152 (1983)
Results are described which demonstrate that the cytotoxic action of 2',5-difluoro-1-arabinosyluracil (FFara-Ura) involves conversion to the corresponding 5'-phosphate, FFara-UMP, and subsequent inhibition of thymidylate synthetase.The evidence for this is as follows: (a) cells lacking thymidine kinase are 120-fold more resistant to FFara-Ura; (b) FFara-Ura markedly inhibits the incorporation of 2'-deoxyuridine (dUrd) into DNA with little or no effect on 2'-deoxythymidine (dThd) incorporation; (c) FFara-Ura causes changes in deoxynucleoside triphosphate pool sizes, which are characteristic of sp ecific inhibition of dTMP synthetase.Binding and spectroscopic studies demonstrate that FFara-UMP inactivates dTMP synthetase from Lactobacillus casei in a manner analogues to that described for FdUMP.Furthermore, FFara-Ura is not a substrate for the pyrimidine phosphorylases; the significance of this finding with regard to the possible chemotherapeutic utility of FFara-Ura is discussed.
