859076-31-6

Basic information

• Product Name: 2-(ethyl(phenyl)amino)propanenitrile
• Synonyms: 2-(ethyl(phenyl)amino)propanenitrile
• CAS NO: 859076-31-6
• Molecular Weight: 174.246
• Mol File: 859076-31-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-(ethyl(phenyl)amino)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(ethyl(phenyl)amino)propanenitrile(859076-31-6)
• EPA Substance Registry System: 2-(ethyl(phenyl)amino)propanenitrile(859076-31-6)

Safety Data

• Hazardous Substances Data: 859076-31-6(Hazardous Substances Data)

Upstream product

• 623-26-7 terephthalonitrile 
• 91-66-7 N,N-diethylaniline 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 62-53-3 aniline 
• 64-17-5 ethanol 
• 7677-24-9 trimethylsilyl cyanide 
• 103-69-5 N-ethyl-N-phenylamine 
• 773837-37-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 75-07-0 acetaldehyde 
• 4348-19-0 N-ethylaniline hydrochloride 

Relevant articles and documents

Visible-Light-Induced α-Amino C-H Bond Arylation Enabled by Electron Donor-Acceptor Complexes

Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, has been disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of tertiary amines and benzonitriles with visible light in N,N-diethylethanamide in the presence of Cs2CO3 afforded α-arylated amines in good to excellent yields.

Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules

Oxidative cyanation of sp3C–H bonds at the α position of amines was achieved using CoCuFe2O4 as a catalyst and NaCN as an inexpensive cyanide source at room temperature. CoCuFe2O4 was found to be an active catalyst for Csp [3]-Csp coupling, efficiently delivering valuable α-aminonitriles from tertiary/secondary amines in good yields. The corresponding products were obtained with high selectivity toward α position. In addition, functional group tolerance offered the opportunity for application in late-stage functionalization of biologically active molecules. This transformation proceeds convenient on a gram-scale, and the catalyst can be reused for several runs with consistent catalytic activity.

Metal-Free Aerobic Oxidative Cyanation of Tertiary Amines: Azobis(isobutyronitrile) (AIBN) as a Sole Cyanide Source

An aerobic oxidative cyanation for the synthesis of α-aminonitriles was reported. The formation of C(sp3)-CN bonds was achieved under a metal-free condition by utilizing azobis(isobutyronitrile) as a sole organic cyanide source with the combination of pivalic acid and sodium acetate as additives.