85918-77-0

Basic information

• Product Name: ethyl 4-(4-fluorophenyl)-2-oxobutanoate
• Synonyms: ethyl 4-(4-fluorophenyl)-2-oxobutanoate
• CAS NO: 85918-77-0
• Molecular Weight: 224.232
• Mol File: 85918-77-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 4-(4-fluorophenyl)-2-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(4-fluorophenyl)-2-oxobutanoate(85918-77-0)
• EPA Substance Registry System: ethyl 4-(4-fluorophenyl)-2-oxobutanoate(85918-77-0)

Safety Data

• Hazardous Substances Data: 85918-77-0(Hazardous Substances Data)

Upstream product

• 332-42-3 (2-bromoethyl)-4-fluorobenzene 
• 95-92-1 oxalic acid diethyl ester 
• 157977-55-4 (4-fluorophenylethyl)magnesium bromide 

Downstream Products

• 1267352-87-3 C₁₀H₉FO₃ 
• 114990-93-1 (R)-2-hydroxy-4-(4-fluorophenyl)butanoic acid 
• 114990-93-1 (S)-2-hydroxy-4-(4-fluorophenyl)butanoic acid 
• 214336-16-0 4-(4-Fluoro-phenyl)-2-oxo-butyric acid isobutyl ester 
• 214336-14-8 4-(4-Fluoro-phenyl)-2-oxo-butyric acid propyl ester 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS AND USE THEREOF

The present invention provides pyrazoles, isoxazoles, isothiazoles, thiadiazoles, and pyridazines according to Formula I as described herein, and pharmaceutically acceptable salts thereof. Pharmaceutical compositions and methods for treating primary hyperoxaluria, type I (PH) and kidney stones are also described.

Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids

The Ru-catalyzed asymmetric hydrogenation of 2-oxo-4-arybutanoic acids to afford 2-hydroxy-4-arybutanoic acids was accomplished by employing SunPhos as chiral ligand and 1 M aq HBr as additive. The high enantioselectivities (88.4%-92.6% ee) and efficiency (TON=10,000, TOF=300 h-1) make this method efficient for the synthesis of an important intermediate, (R)-2-hydroxy-4-phenylbutanoic acid, for ACE inhibitors.