859224-90-1

Basic information

• Product Name: (1R,2S,3R,5S)-5-((3-amino-5-(methoxycarbonyl)phenyl)carbamoyl)cyclohexane-1,2,3,5-tetrayltetraacetate
• Synonyms: (1R,2S,3R,5S)-5-((3-amino-5-(methoxycarbonyl)phenyl)carbamoyl)cyclohexane-1,2,3,5-tetrayltetraacetate
• CAS NO: 859224-90-1
• Molecular Weight: 508.482
• Mol File: 859224-90-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R,2S,3R,5S)-5-((3-amino-5-(methoxycarbonyl)phenyl)carbamoyl)cyclohexane-1,2,3,5-tetrayltetraacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,3R,5S)-5-((3-amino-5-(methoxycarbonyl)phenyl)carbamoyl)cyclohexane-1,2,3,5-tetrayltetraacetate(859224-90-1)
• EPA Substance Registry System: (1R,2S,3R,5S)-5-((3-amino-5-(methoxycarbonyl)phenyl)carbamoyl)cyclohexane-1,2,3,5-tetrayltetraacetate(859224-90-1)

Safety Data

• Hazardous Substances Data: 859224-90-1(Hazardous Substances Data)

Upstream product

• 32469-24-2 (1R,3R,4R,5R)-(-)-quinic acid tetraacetate 
• 1949-55-9 methyl 3,5-diaminobenzoate 
• 77-95-2 D-(-)-quinic acid 
• 87396-23-4 1,2,3-benzotriazol-1-yl D(-)-1,3,4,5-tetraacetoxycyclohexane-1-carboxylate 

Relevant articles and documents

QUINIC ACID-MODIFIED NANOPARTICLES AND USES THEREOF

The present invention generally relates to targeted nanoparticle delivery to E-selectin- or P-selectin-positive cells or tissues. In particular, this invention discloses a method for preparing quinic acid-modified nanoparticles for targeted drug delivery

Quinic acid derivatives as sialyl Lewisx-mimicking selectin inhibitors: Design, synthesis, and crystal structure in complex with E-selectin

A search for noncarbohydrate sLex mimics led to the development of quinic acid derivatives as selectin inhibitors. At Wyeth we solved the first cocrystal structure of a small molecule, quinic acid, with E-selectin. In the cocomplex two hydroxyls of quinic acid mimic the calcium-bound fucose of the tetrasaccharide sLex. The X-ray structure, together with structure based computational methods, was used to design quinic acid based libraries that were synthesized and evaluated for their ability to block the interaction of sLex with P-selectin. A large number of analogues were prepared using solution-phase parallel synthesis. Selected compounds showed decrease in leukocyte rolling in the IVM mouse model. Compound 2 inhibited neutrophil influx in the murine TIP model and demonstrated good plasma exposure.