85952-31-4

Basic information

• Product Name: (2,6-dichlorophenyl)methanesulfonyl chloride
• Synonyms: (2,6-dichlorophenyl)methanesulfonyl chloride;(2,6-Dichlorophenyl)methylsulphonyl chloride;2,6-Dichlorobenzylsulphonyl chloride;(2,6-Dichlorophenyl)methanesulphonyl chloride;alpha-(Chlorosulphonyl)-2,6-dichlorotoluene;2,6-Dichlorobenzylsulfonyl chloride
• CAS NO: 85952-31-4
• Molecular Formula: C₇H₅Cl₃O₂S
• Molecular Weight: 259.54
• Mol File: 85952-31-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2,6-dichlorophenyl)methanesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2,6-dichlorophenyl)methanesulfonyl chloride(85952-31-4)
• EPA Substance Registry System: (2,6-dichlorophenyl)methanesulfonyl chloride(85952-31-4)

Safety Data

• Hazardous Substances Data: 85952-31-4(Hazardous Substances Data)

Usage

General Description

(2,6-dichlorophenyl)methanesulfonyl chloride, also known as 2,6-Diclorobenzylsulfonylchlorid, is a chemical compound with the molecular formula C7H6Cl2O2S. It is a sulfonyl chloride derivative of dichlorobenzene, and it is commonly used as a reagent for the synthesis of organic compounds. This chemical is a strong acylating agent and is often used in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used in the synthesis of various sulfonamides, which are important compounds in medicinal chemistry. 2,6-dichlorophenyl)methanesulfonyl chloride can react with a variety of nucleophiles, such as amines and alcohols, to form sulfonamide and sulfonate ester compounds, respectively. The compound is a white to slightly yellow solid that is soluble in organic solvents, and it should be handled with caution due to its reactivity and potential for causing skin and eye irritation.

Upstream product

• 1154613-75-8 sodium (2,6-dichloro-phenyl)-methanesulfonic acid 
• 65051-35-6 (2,6-dichlorobenzylthio)-acetic acid 
• 2014-83-7 1,3-Dichloro-2-chloromethyl-benzene 

Downstream Products

• 1417156-43-4 1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide 
• 1417156-29-6 N-allyl-1-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)methanesulfonamide 
• 103482-25-3 2,6-dichlorobenzylsulfonamide 

Relevant articles and documents

Access to a wide range of sultams by cyclodialkylation of α-substituted methanesulfonanilides

A wide range of five- and six-membered sultams bearing an α-ethoxycarbonyl-α-methyl substituent or an α-aryl group (17 examples) were synthesized by the cyclodialkylation of α-substituted methanesulfonanilides with α,ω-dihaloalkanes in the presence of K2CO3 or under phase-transfer catalysis (PTC) conditions. Upon treatment with K2CO3 in N,N-dimethylformamide (DMF) or NaH in dimethyl sulfoxide (DMSO), N-(2,3-dibromopropyl)-α- toluenesulfonanilides furnished different 1,3-diaryl-2-thia-3-azabicyclo[3.1.0] hexane 2,2-dioxides in good to excellent yields (51-88 %, 16 examples). The 4-methoxyphenyl (PMP) group was easily removed from the sultam nitrogen atom by treatment of the corresponding bicyclic sultams with cerium(IV) ammonium nitrate in acetonitrile (71-84 % yield, 6 examples). The intermolecular cyclodialkylation of α-substituted methanesulfonamides constitutes a simple and efficient route to five- and six-membered sultams with α-ethoxycarbonyl-α-methyl or α-aryl substitution. The intramolecular cyclodialkylation of N-(2,3-dibromopropyl)-α- toluenesulfanilides readily leads to bicyclic sultams bearing a cyclopropane ring. Copyright

Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis

This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds in the treating or preventing thrombosis in a mammal, or preventing progression of symptoms of thrombosis.

Process for making an aldehyde

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.