85952-31-4

Usage

Uses

Used in Pharmaceutical Industry:
(2,6-dichlorophenyl)methanesulfonyl chloride is used as a reagent for the synthesis of various pharmaceuticals. It is involved in the preparation of sulfonamide and sulfonate ester compounds, which are important in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical industry, (2,6-dichlorophenyl)methanesulfonyl chloride is used as a reagent for the synthesis of various agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Specialty Chemicals Industry:
(2,6-dichlorophenyl)methanesulfonyl chloride is also used in the synthesis of specialty chemicals, where its strong acylating properties are utilized to create a range of chemical compounds for specific applications.
It is important to handle (2,6-dichlorophenyl)methanesulfonyl chloride with caution due to its reactivity and potential for causing skin and eye irritation.

Upstream product

• 2014-83-7 1,3-Dichloro-2-chloromethyl-benzene 
• 1154613-75-8 sodium (2,6-dichloro-phenyl)-methanesulfonic acid 
• 65051-35-6 (2,6-dichlorobenzylthio)-acetic acid 

Downstream Products

• 1417156-29-6 N-allyl-1-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)methanesulfonamide 
• 1417156-43-4 1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide 
• 103482-25-3 2,6-dichlorobenzylsulfonamide 

Relevant academic research and scientific papers

Access to a wide range of sultams by cyclodialkylation of α-substituted methanesulfonanilides

A wide range of five- and six-membered sultams bearing an α-ethoxycarbonyl-α-methyl substituent or an α-aryl group (17 examples) were synthesized by the cyclodialkylation of α-substituted methanesulfonanilides with α,ω-dihaloalkanes in the presence of K2CO3 or under phase-transfer catalysis (PTC) conditions. Upon treatment with K2CO3 in N,N-dimethylformamide (DMF) or NaH in dimethyl sulfoxide (DMSO), N-(2,3-dibromopropyl)-α- toluenesulfonanilides furnished different 1,3-diaryl-2-thia-3-azabicyclo[3.1.0] hexane 2,2-dioxides in good to excellent yields (51-88 %, 16 examples). The 4-methoxyphenyl (PMP) group was easily removed from the sultam nitrogen atom by treatment of the corresponding bicyclic sultams with cerium(IV) ammonium nitrate in acetonitrile (71-84 % yield, 6 examples). The intermolecular cyclodialkylation of α-substituted methanesulfonamides constitutes a simple and efficient route to five- and six-membered sultams with α-ethoxycarbonyl-α-methyl or α-aryl substitution. The intramolecular cyclodialkylation of N-(2,3-dibromopropyl)-α- toluenesulfanilides readily leads to bicyclic sultams bearing a cyclopropane ring. Copyright

HERBICIDAL COMPOUNDS

The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4 and R5 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processe

Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis

This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds in the treating or preventing thrombosis in a mammal, or preventing progression of symptoms of thrombosis.

INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2

This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLAα). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.

Process for making an aldehyde

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.

IL-8 RECEPTOR ANTAGONISTS

This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). Compounds of Formnula (I) are represented, interalia, by structure (I) wherein i

IL-8 receptor antagonists

This invention relates to novel spiro compound derivatives of benzoisothiazolyl-urea and -thiourea and compositions thereof. These compounds are useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

Evolution of anti-HIV drug candidates. Part 1: From α-Anilinophenylacetamide (α-APA) to imidoyl thiourea (ITU)

Stemming from work on a previous clinical candidate, loviride, and other α-APA derivatives, a new series of potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been synthesized. The ITU analogues, which contain a unique diarylated imidoyl thiourea, are very active in inhibiting both wild-type and clinically important mutant strains of HIV-1.