85953-41-9

Usage

Structure

A sulfonamide derivative of indole

Usage

Building block in the synthesis of pharmaceuticals and other organic compounds

Appearance

White to off-white solid

Solubility

Sparingly soluble in water and ethanol

Applications

Preparation of antifungal agents, studied for potential medicinal properties

Safety

Handle and store with care, may pose health hazards if not properly maintained

Upstream product

• 120-72-9 indole 
• 104-12-1 p-chlorphenylisocyanate 
• 85953-39-5 1-phenylsulfonyl-1H-indole-2-sulfonyl chloride 
• 40899-71-6 1-benzenesulfonylindole 
• 85953-40-8 1-(phenylsulfonyl)indole-2-sulfonamide 

Relevant academic research and scientific papers

A convenient synthesis of sulfonylureas from carboxylic acids and sulfonamides via an in situ Curtius rearrangement

A one-pot reaction of carboxylic acids with sulfonamides to afford sulfonylureas is described.

Antitumor compositions and methods of treatment

This invention provides the use of certain benzofuransulfonamide, benzothiophenesulfonamide, and indolesulfonamide derivatives in the treatment of susceptible neoplasms in mammals. Also provided are certain novel benzofuransulfonamide and benzothiophenesulfonamide derivatives and their pharmaceutical formulations.

Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides

Derivatives of benzofuran- and indole-2-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. These compounds were found to be excellent inhibitors of carbonic anhydrase and to lower intraocular pressure in a rabbit model

Herbicidal indole sulfonamides

This invention relates to novel N-(heterocyclicaminocarbonyl) indole sulfonamides which are useful as agricultural chemicals and, in particular, as herbicides.