859732-45-9

Upstream product

• 455-18-5 4-CF₃C₆H₄CN 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 15816-25-8 4-(trifluoromethyl)benzenimidic acid ethyl ester hydrochloride 
• 570-24-1 2-Methyl-6-nitroaniline 
• 3300-51-4 p-Trifluoromethylbenzylamine 
• 1891-90-3 p-trifluoromethylbenzamide 
• 29289-13-2 2-iodo-4-methylaniline 

Relevant academic research and scientific papers

Cu(I)-catalyzed synthesis of 2-substituted benzimidazoles from 2-iodoanilines and amides

A novel and efficient approach to the synthesis of 2-substituted benzimidazoles has been developed via CuI/DMEDA-catalyzed coupling reaction and post-cyclization with glacial acetic acid from readily available 2-iodoanilines and amides. This method is suitable for the construction of a variety of benzimidazoles in moderate to good yields under short reaction times. A novel and efficient approach to the synthesis of 2-substituted benzimidazoles has been developed via CuI/DMEDA-catalyzed coupling reaction and post-cyclization with glacial acetic acid from readily available 2-iodoanilines and amides. This method is suitable for the construction of a variety of benzimidazoles in moderate to good yields under short reaction times. Copyright

Transition-Metal-Free Transfer Hydrogenative Cascade Reaction of Nitroarenes with Amines/Alcohols: Redox-Economical Access to Benzimidazoles

This report describes an efficient transition-metal-free process toward the transfer hydrogenative cascade reaction between nitroarenes and amines or alcohols. The developed redox-economical approach was realized using a combination of KOtBu and Et3SiH as reagents, which allows the synthesis of benzimidazole derivatives via σ-bond metathesis. The reaction conditions hold well over a wide range of substrates embedded with diverse functional groups to deliver the desired products in good to excellent yields. The mechanistic proposal has been depicted on the basis of a series of control experiments, mass spectroscopic evidence which is well supported by density functional theory (DFT) calculations with a feasible energy profile.

Microwave-assisted synthesis and biological evaluation of some benzimidazole derivatives containing a 1,2,4-Triazol Ring

A new series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique. This efficient procedure provides pure products within a few minutes. The newly synthesized compounds were confirmed by 1H NMR and 13C NMR spectra and they were screened for their lipase inhibition and antioxidant activities. Compounds 4a, 4b, 5a, and 5b showed very good scavenging activity. A series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d] imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique and screened for their lipase inhibition and antioxidant activities. Compounds 4a, 4b, 5a, and 5b showed very good scavenging activity.