859785-14-1

Basic information

• Product Name: Benzenepentanoic acid, 2,3,4-trimethoxy-
• Synonyms: 5-(2',3',4'-trimethoxyphenyl)pentanoic acid;5-(2,3,4-trimethoxy-phenyl)-valeric acid;Benzenepentanoic acid,2,3,4-trimethoxy;5-(2,3,4-Trimethoxy-phenyl)-valeriansaeure
• CAS NO: 859785-14-1
• Molecular Formula: C14H20O5
• Molecular Weight: 268.31
• Mol File: 859785-14-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 66-67 °C
• Boiling Point: 200-210 °C(Press: 0.15 Torr)
• Density: 1.125±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenepentanoic acid, 2,3,4-trimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepentanoic acid, 2,3,4-trimethoxy-(859785-14-1)
• EPA Substance Registry System: Benzenepentanoic acid, 2,3,4-trimethoxy-(859785-14-1)

Safety Data

• Hazardous Substances Data: 859785-14-1(Hazardous Substances Data)

Upstream product

• 79623-04-4 5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid 
• 77-78-1 dimethyl sulfate 
• 25245-37-8 1-iodo-2,3,4-trimethoxy-benzene 
• 1378238-61-9 (Z)/(E)-5-(2',3',4'-trimethoxyphenyl)pent-4-enoic acid 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 
• 634-36-6 1,2,3-trimethoxybenzene 
• 108-55-4 glutaric anhydride, 
• 16093-16-6 5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid 

Downstream Products

• 1378238-69-7 2-[(tert-butyldimethylsilyl)oxy]-1,3-dimethoxy-5-(3',4',5'-trimethoxyphenyl)-benzocycloheptan-5-ol 
• 1378238-70-0 1,3-dimethoxy-2-hydroxy-5-(3',4',5'-trimethoxyphenyl)benzocyclohept-5-ene 

Relevant articles and documents

Pd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generatedviaC(sp3)-H activation

Transition-metal-catalyzed cross-electrophile C(sp2)-(sp3) coupling and C-H alkylation reactions represent two efficient methods for the incorporation of an alkyl group into aromatic rings. Herein, we report a Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides. Methoxy and benzyloxy groups, which are ubiquitous functional groups and common protecting groups, were utilized as crucial mediatorsviaprimary or secondary C(sp3)-H activation. The reaction provides an innovative and convenient access for the synthesis of alkylated phenol derivatives, which are widely found in bioactive compounds and organic functional materials.

Efficient Method for Preparing Functionalized Benzosuberenes

The disclosed process can efficiently synthesize functionalized benzosuberenes. The process provides an improved method of production of benzosuberene and compounds containing a benzosuberene moiety, which is characterized by a ring closing methodology comprising reaction of a 5-phenylpentanoic acid with Eaton's reagent to form the benzosuberone. The process, optionally, further includes steps for adding a functional group at the ketone position.