859850-72-9

Basic information

• Product Name: (3-PYRROLIDIN-1-YLPHENYL)METHANOL
• Synonyms: (3-PYRROLIDIN-1-YLPHENYL)METHANOL;Benzenemethanol,3-(1-pyrrolidinyl)-
• CAS NO: 859850-72-9
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 859850-72-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 344.1°C at 760 mmHg
• Flash Point: 188.2°C
• Appearance: /
• Density: 1.123g/cm³
• Vapor Pressure: 2.57E-05mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: (3-PYRROLIDIN-1-YLPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (3-PYRROLIDIN-1-YLPHENYL)METHANOL(859850-72-9)
• EPA Substance Registry System: (3-PYRROLIDIN-1-YLPHENYL)METHANOL(859850-72-9)

Safety Data

• Hazardous Substances Data: 859850-72-9(Hazardous Substances Data)

Usage

General Description

(3-Pyrrolidin-1-ylphenyl)methanol is a chemical compound that belongs to the class of phenylmethanols and contains a pyrrolidine ring. It is commonly used in the pharmaceutical and research industries as a building block for the synthesis of various organic compounds. This chemical compound has potential applications in medicinal chemistry, particularly in the development of drugs for various therapeutic purposes. The structural features and functional groups of (3-Pyrrolidin-1-ylphenyl)methanol make it a valuable component in the synthesis of biologically active molecules and pharmaceuticals. Its properties and reactivity make it a versatile compound with the potential for diverse applications in the field of chemical and pharmaceutical research.

InChI:InChI=1/C11H15NO/c13-9-10-4-3-5-11(8-10)12-6-1-2-7-12/h3-5,8,13H,1-2,6-7,9H2

Upstream product

• 618-91-7 methyl 3-iodo-benzoate 
• 186086-71-5 N-(3-carbomethoxyphenyl)pyrrolidine 
• 110-52-1 1,4-dibromo-butane 
• 1877-77-6 3-aminobenzenemethanol 

Relevant articles and documents

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

The free fatty acid receptor 1 (FFA1) has gained significant interest as a novel antidiabetic target. Most of FFA1 agonists reported in the literature bearing a common biphenyl scaffold, which was crucial for toxicity verified by the researchers of Daiichi Sankyo. Herein, we describe the systematic exploration of non-biphenyl scaffold and further chemical modification of the optimal pyrrole scaffold. All of these efforts led to the identification of compound 11 as a potent and orally bioavailable FFA1 agonist without the risk of hypoglycemia. Further molecular modeling studies promoted the understanding of ligand-binding pocket and might help to design more promising FFA1 agonists.

Substituted alkylamine derivatives

The substituted alkylamine derivatives represented by formula (I) STR1 wherein R1 represents (a) substituted or unsubstituted C2-6 alkenyl group, (b) substituted or unsubstituted C3-6 cycloalkenyl group, (c) substituted or unsubstituted C2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru11 -Ar wherein R11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; STR2 represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R7, X and Y are linking groups, R2 is H or lower alkyl, R3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl, R4 and R5 are independently hydrogen or halogen atoms, R6 represents (a) substituted or unsubstituted acyclic hydrocarbon group which may be unsaturated, (b) substituted or unsubstituted cycloalkyl group, or (c) substituted or unsubstituted phenyl group, or non-toxic salts thereof. (E)-N-(6-6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[4-(3-thienyl)-2-thienyl-methyloxy]benzylamine hydrochloride is a representative example. The substituted alkylamine derivatives are useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.