860013-76-9

Upstream product

• 860013-73-6 E-trifluoro-methanesulfonic acid (4-benzyl-morpholin-2-ylidene)-phenyl-methyl ester 
• 521969-46-0 (4-benzyl-morpholin-2-yl)-phenylmethanone 

Relevant academic research and scientific papers

Straightforward synthesis of (R,R/S,S)-2-[2-(2-aryl)-1-phenyl-ethyl]-morpholines: a new class of inhibitors of the norepinephrine transporter

Diastereoselective synthesis of (R,R/S,S)-2-[2-(2-aryl)-1-phenyl-ethyl]-morpholines 6 has been achieved through the preparation of key E-enol-triflate 4 and its further coupling with benzylzinc reagents and final hydrogenation.

MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS

Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.