860194-90-7 Usage
Uses
Used in Medicinal Chemistry:
3-Bromo-4,7-dichloroquinoline is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemicals:
3-Bromo-4,7-dichloroquinoline is used as a building block in the creation of agrochemicals, specifically crop protection agents. Its properties make it a valuable component in the development of effective and targeted pest control solutions.
Used in Drug Discovery:
3-Bromo-4,7-dichloroquinoline is used as a starting material in drug discovery processes. Its unique chemical structure provides a foundation for the design and synthesis of novel compounds with potential medicinal properties.
It is important to handle 3-bromo-4,7-dichloroquinoline with care and follow proper safety protocols due to its potentially hazardous nature.
Check Digit Verification of cas no
The CAS Registry Mumber 860194-90-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,0,1,9 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 860194-90:
(8*8)+(7*6)+(6*0)+(5*1)+(4*9)+(3*4)+(2*9)+(1*0)=177
177 % 10 = 7
So 860194-90-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H4BrCl2N/c10-7-4-13-8-3-5(11)1-2-6(8)9(7)12/h1-4H
860194-90-7Relevant academic research and scientific papers
ANALOGUES OF HYDROXYCHLOROQUINE (HCQ) WITHOUT RETINAL TOXICITY
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Paragraph 0303-0304, (2019/03/08)
The present invention relates to hydroxychloroquine analogues having an activity superior to that of hydroxychloroquine but free from retinal cytotoxicity of formula (I), their pharmaceutically acceptable salts, solvates or hydrates: their method of prepa
Base-Controlled Regioselective Functionalization of Chloro-Substituted Quinolines
Murie, Valter E.,Nishimura, Rodolfo H. V.,Rolim, Larissa A.,Vessecchi, Ricardo,Lopes, Norberto P.,Clososki, Giuliano C.
, p. 871 - 880 (2018/01/28)
We prepared a number of di- and trifunctionalized quinolines by selective metalation of chloro-substituted quinolines with metal amides followed by reaction with different electrophiles. Metalation of the C-3 position of the quinolinic ring with lithium diisopropylamide at -70 °C is easy to achieve, whereas reaction with lithium-magnesium and lithium-zinc amides affords C-2 or C-8 functionalized derivatives in a regioselective fashion. These complementary methods could be rationalized by DFT calculations and are convenient strategies toward the synthesis of bioactive quinoline derivatives such as chloroquine analogues.
