860294-07-1Relevant academic research and scientific papers
Effect of substituents on diarylmethanes for antitubercular activity
Panda, Gautam,Parai, Maloy Kumar,Das, Sajal Kumar,Shagufta,Sinha, Manish,Chaturvedi, Vinita,Srivastava, Anil K.,Manju,Gaikwad, Anil N.,Sinha, Sudhir
, p. 410 - 419 (2008/02/02)
Aminoalkyl derivatives of diarylmethanes were prepared using Grignard, Friedel-Crafts arylation and aminohydrochloride chain formation reactions. These series of compounds were evaluated against Mycobacterium tuberculosis H37Rv and s
Hard-soft acid-base (HSAB) principle and difference in d-orbital configurations of metals explain the regioselectivity of nucleophilic attack to a carbinol in Friedel-Crafts reaction catalyzed by Lewis and protonic acids
Panda, Gautam,Mishra, Jitendra K.,Shagufta,Dinadayalane,Sastry, G. Narahari,Negi, Devendra S.
, p. 276 - 287 (2007/10/03)
The alkylations of aromatic compounds in presence of protonic acids yield two alkylated products arising from attack of a nucleophile (hard or soft) at two different carbocation (hard or soft) centers of a single compound. Hybrid density functional theory at B3LYP/6-31G* and B3LYP/6-31G levels and semiempirical calculations are employed to explain the observed trends in Friedel-Crafts reaction. Local HSAB principle based on local softness values explains the observed experimental reactivities.
