860299-07-6Relevant academic research and scientific papers
Efficient cesium carbonate promoted N-alkylations of aromatic cyclic imides under microwave irradiation
Escudero, Mercedes Isasmendi,Kremenchuzky, Lautaro D.,Perillo, Isabel A.,Cerecetto, Hugo,Blanco, Maria M.
experimental part, p. 571 - 576 (2011/04/15)
We present here an efficient and simple method for the N-alkylation of aromatic cyclic imides employing cesium carbonate as the base in anhydrous N,N-dimethylformamide at low temperatures (20-70 °C). The employment of microwave irradiation presents noteworthy advantages over conventional heating. The method is compatible with base labile functional groups. Georg Thieme Verlag Stuttgart - New York.
1,6- And 1,7-naphthyridines. IV. Synthesis of hydroxycarboxamide derivatives
Blanco, M. Mercedes,Schapira, Celia B.,Levin, Gustavo,Perillo, Isabel A.
, p. 493 - 502 (2007/10/03)
A series of 8-hydroxy-1,6-naphthyridin-5(6H)-one-7-carboxamides 1 and the isomeric 5-hydroxy-1,7-naphthyridin-8(7H)-one-6-carboxamides 2 were synthesized. N-Lactam unsubstituted compounds 1a-c and 2a,b were obtained by alkoxide-induced rearrangement of the corresponding quinolinimidoacetamides 3. Compounds 1e,f and 2e,f were synthesized by heterocyclization of the corresponding quinolinamic esters 6 and 7. Spectroscopic properties (uv, ir, 1H and 13C nmr and ms) were analyzed and the proposed structures confirmed.
